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Goat Anti-COMT (N Terminus) Antibody

Peptide-affinity purified goat antibody

  • WB - Goat Anti-COMT (N Terminus) Antibody AF1265b
    Staining of human testis lysate (35 µg protein in RIPA buffer) with AF1265b (0.3 µg/ml). Primary incubation was 1 hour. Detected by chemiluminescence.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession P21964
Other Accession NP_009294, 1312
Reactivity Human
Predicted Mouse, Rat, Dog
Host Goat
Clonality Polyclonal
Concentration 100ug/200ul
Isotype IgG
Calculated MW 30037 Da
Additional Information
Gene ID 1312
Other Names Catechol O-methyltransferase,, COMT
Format 0.5 mg IgG/ml in Tris saline (20mM Tris pH7.3, 150mM NaCl), 0.02% sodium azide, with 0.5% bovine serum albumin
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsGoat Anti-COMT (N Terminus) Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Function Catalyzes the O-methylation, and thereby the inactivation, of catecholamine neurotransmitters and catechol hormones. Also shortens the biological half-lives of certain neuroactive drugs, like L-DOPA, alpha-methyl DOPA and isoproterenol.
Cellular Location Isoform Soluble: Cytoplasm.
Tissue Location Brain, liver, placenta, lymphocytes and erythrocytes
Research Areas
Citations (0)

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Catechol-O-methyltransferase catalyzes the transfer of a methyl group from S-adenosylmethionine to catecholamines, including the neurotransmitters dopamine, epinephrine, and norepinephrine. This O-methylation results in one of the major degradative pathways of the catecholamine transmitters. In addition to its role in the metabolism of endogenous substances, COMT is important in the metabolism of catechol drugs used in the treatment of hypertension, asthma, and Parkinson disease. COMT is found in two forms in tissues, a soluble form (S-COMT) and a membrane-bound form (MB-COMT). The differences between S-COMT and MB-COMT reside within the N-termini. Several transcript variants are formed through the use of alternative translation initiation sites and promoters.


Effects of modafinil on the sleep EEG depend on Val158Met genotype of COMT. Bodenmann S, et al. Sleep, 2010 Aug 1. PMID 20815183.
Impact of aerobic exercise training on cognitive functions and affect associated to the COMT polymorphism in young adults. Stroth S, et al. Neurobiol Learn Mem, 2010 Aug 26. PMID 20800689.
DAT1 and COMT Effects on Delay Discounting and Trait Impulsivity in Male Adolescents with Attention Deficit/Hyperactivity Disorder and Healthy Controls. Paloyelis Y, et al. Neuropsychopharmacology, 2010 Aug 25. PMID 20736997.
Genetic polymorphism of catechol-O-methyltransferase and cytochrome P450c17伪 in preeclampsia. Lim JH, et al. Pharmacogenet Genomics, 2010 Oct. PMID 20729792.
Association between Novelty Seeking of opiate-dependent patients and the catechol-O-methyltransferase Val(158)Met polymorphism. Demetrovics Z, et al. Compr Psychiatry, 2010 Sep-Oct. PMID 20728009.

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$ 325.00
Cat# AF1265b
(40 western blots)
Availability: 7-10 days
Bulk Size
Seasonal Special on Bulk Order
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