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COMT (N Terminus) AntibodyPeptide-affinity purified goat antibody
| Country | United States
Ordering Information
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| Catalog # | Size | Availability | Price | |
| AF1265b | 0.1mg 400 ul | 7-10 days | $ 325.00 | DISCONTINED INQUIRE CLICK INQUIRE Add to cart |
- Specification
- Citiations : 0
- Reviews
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- Backgrounds
COMT (N Terminus) Antibody - Product info | |
| Other Accession | NP_009294 |
| Reactivity | Human |
| Concentration | 100ug/200ul |
| Isotype | IgG |
COMT (N Terminus) Antibody - Additional info | |
| Other Names COMT; catechol-O-methyltransferase; OTTHUMP00000197749; OTTHUMP00000197750 | |
| Format 0.5 mg IgG/ml in Tris saline (20mM Tris pH7.3, 150mM NaCl), 0.02% sodium azide, with 0.5% bovine serum albumin | |
| Storage Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. | |
| Precautions COMT (N Terminus) Antibody is for research use only and not for use in diagnostic or therapeutic procedures. | |
COMT (N Terminus) Antibody - Application data
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Staining of human testis lysate (35 µg protein in RIPA buffer) with AF1265b (0.2 µg/ml). Primary incubation was 1 hour. Detected by chemiluminescence.
COMT (N Terminus) Antibody - Related products
AP10956a: COMT Antibody (N-term)
LY10302a: COMT Over-expression Lysate
AT1588a: COMT Antibody (monoclonal) (M01)
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Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
Catechol-O-methyltransferase catalyzes the transfer of a methyl group from S-adenosylmethionine to catecholamines, including the neurotransmitters dopamine, epinephrine, and norepinephrine. This O-methylation results in one of the major degradative pathways of the catecholamine transmitters. In addition to its role in the metabolism of endogenous substances, COMT is important in the metabolism of catechol drugs used in the treatment of hypertension, asthma, and Parkinson disease. COMT is found in two forms in tissues, a soluble form (S-COMT) and a membrane-bound form (MB-COMT). The differences between S-COMT and MB-COMT reside within the N-termini. Several transcript variants are formed through the use of alternative translation initiation sites and promoters.
REFERENCES
Effects of modafinil on the sleep EEG depend on Val158Met genotype of COMT. Bodenmann S, et al. Sleep, 2010 Aug 1. PMID 20815183. Impact of aerobic exercise training on cognitive functions and affect associated to the COMT polymorphism in young adults. Stroth S, et al. Neurobiol Learn Mem, 2010 Aug 26. PMID 20800689. DAT1 and COMT Effects on Delay Discounting and Trait Impulsivity in Male Adolescents with Attention Deficit/Hyperactivity Disorder and Healthy Controls. Paloyelis Y, et al. Neuropsychopharmacology, 2010 Aug 25. PMID 20736997. Genetic polymorphism of catechol-O-methyltransferase and cytochrome P450c17伪 in preeclampsia. Lim JH, et al. Pharmacogenet Genomics, 2010 Oct. PMID 20729792. Association between Novelty Seeking of opiate-dependent patients and the catechol-O-methyltransferase Val(158)Met polymorphism. Demetrovics Z, et al. Compr Psychiatry, 2010 Sep-Oct. PMID 20728009.
