|Application ||WB, E|
|Other Accession||NP_009005, 11151, 12721 (mouse), 155151 (rat)|
|Predicted||Rat, Dog, Cow|
|Calculated MW||51026 Da|
|Other Names||Coronin-1A, Coronin-like protein A, Clipin-A, Coronin-like protein p57, Tryptophan aspartate-containing coat protein, TACO, CORO1A, CORO1|
|Format||0.5 mg IgG/ml in Tris saline (20mM Tris pH7.3, 150mM NaCl), 0.02% sodium azide, with 0.5% bovine serum albumin|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||Goat Anti-Coronin 1 / TACO Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||May be a crucial component of the cytoskeleton of highly motile cells, functioning both in the invagination of large pieces of plasma membrane, as well as in forming protrusions of the plasma membrane involved in cell locomotion. In mycobacteria- infected cells, its retention on the phagosomal membrane prevents fusion between phagosomes and lysosomes.|
|Cellular Location||Cytoplasm, cytoskeleton. Cytoplasm, cell cortex. Cytoplasmic vesicle, phagosome membrane. Note=In non-infected macrophages, associated with the cortical microtubule network. In mycobacteria-infected macrophages, becomes progressively relocalized and retained around the mycobacterial phagosomes Retention on the phagosomal membrane is strictly dependent on mycobacterial viability and not due to impaired acidification (By similarity).|
|Tissue Location||Expressed in brain, thymus, spleen, bone marrow and lymph node. Low in lung and gut|
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This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD), which may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular processes, including cell cycle progression, signal transduction, apoptosis, and gene regulation. Alternative splicing results in multiple transcript variants. A related pseudogene has been defined on chromosome 16.
Coronin-1 is associated with neutrophil survival and is cleaved during apoptosis: potential implication in neutrophils from cystic fibrosis patients. Moriceau S, et al. J Immunol, 2009 Jun 1. PMID 19454722.
The actin regulator coronin 1A is mutant in a thymic egress-deficient mouse strain and in a patient with severe combined immunodeficiency. Shiow LR, et al. Nat Immunol, 2008 Nov. PMID 18836449.
Phorbol ester-dependent phosphorylation regulates the association of p57/coronin-1 with the actin cytoskeleton. Oku T, et al. J Biol Chem, 2008 Oct 24. PMID 18693254.
Coronin function is required for chemotaxis and phagocytosis in human neutrophils. Yan M, et al. J Immunol, 2007 May 1. PMID 17442961.
Large-scale mapping of human protein-protein interactions by mass spectrometry. Ewing RM, et al. Mol Syst Biol, 2007. PMID 17353931.
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