|Application ||WB, E|
|Other Accession||NP_055140, 23603|
|Calculated MW||53249 Da|
|Other Names||Coronin-1C, Coronin-3, hCRNN4, CORO1C, CRN2, CRNN4|
|Format||0.5 mg IgG/ml in Tris saline (20mM Tris pH7.3, 150mM NaCl), 0.02% sodium azide, with 0.5% bovine serum albumin|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||Goat Anti-Coronin 3 / coronin 1C Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||May be involved in cytokinesis, motility, and signal transduction.|
|Cellular Location||Cell membrane. Cell projection, lamellipodium Cytoplasm, cytoskeleton. Note=All isoforms localize in a diffuse and punctate pattern in the cytosol and are highly enriched in F-actin-rich areas. Isoform 3 colocalizes with the thin filaments of the sarcomere and with the postsynaptic area and the junctional sarcoplasm of motor end plates|
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Provided below are standard protocols that you may find useful for product applications.
This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD), which may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular processes, including cell cycle progression, signal transduction, apoptosis, and gene regulation.
Polymorphisms in innate immunity genes and risk of childhood leukemia. Han S, et al. Hum Immunol, 2010 Jul. PMID 20438785.
Risk of meningioma and common variation in genes related to innate immunity. Rajaraman P, et al. Cancer Epidemiol Biomarkers Prev, 2010 May. PMID 20406964.
Coronin 1C negatively regulates cell-matrix adhesion and motility of intestinal epithelial cells. Samarin SN, et al. Biochem Biophys Res Commun, 2010 Jan 1. PMID 19913511.
Structural and functional diversity of novel coronin 1C (CRN2) isoforms in muscle. Xavier CP, et al. J Mol Biol, 2009 Oct 23. PMID 19651142.
Defining the human deubiquitinating enzyme interaction landscape. Sowa ME, et al. Cell, 2009 Jul 23. PMID 19615732.
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