Goat Anti-CRP2 / CSRP2 Antibody
Peptide-affinity purified goat antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| WB, IHC, E |
---|---|
Primary Accession | Q16527 |
Other Accession | NP_001312, 1466, 13008 (mouse) |
Reactivity | Human, Mouse, Rat |
Predicted | Horse |
Host | Goat |
Clonality | Polyclonal |
Concentration | 100ug/200ul |
Isotype | IgG |
Calculated MW | 20954 Da |
Gene ID | 1466 |
---|---|
Other Names | Cysteine and glycine-rich protein 2, Cysteine-rich protein 2, CRP2, LIM domain only protein 5, LMO-5, Smooth muscle cell LIM protein, SmLIM, CSRP2, LMO5, SMLIM |
Format | 0.5 mg IgG/ml in Tris saline (20mM Tris pH7.3, 150mM NaCl), 0.02% sodium azide, with 0.5% bovine serum albumin |
Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
Precautions | Goat Anti-CRP2 / CSRP2 Antibody is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | CSRP2 |
---|---|
Synonyms | LMO5, SMLIM |
Function | Drastically down-regulated in response to PDGF-BB or cell injury, that promote smooth muscle cell proliferation and dedifferentiation. Seems to play a role in the development of the embryonic vascular system. |
Cellular Location | Nucleus. |
Tissue Location | Highly expressed in the aorta, but not in heart and skeletal muscle |
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Provided below are standard protocols that you may find useful for product applications.
Background
CSRP2 is a member of the CSRP family of genes, encoding a group of LIM domain proteins, which may be involved in regulatory processes important for development and cellular differentiation. CRP2 contains two copies of the cysteine-rich amino acid sequence motif (LIM) with putative zinc-binding activity, and may be involved in regulating ordered cell growth. Other genes in the family include CSRP1 and CSRP3.
References
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Gerhard DS, et al. Genome Res, 2004 Oct. PMID 15489334.
Interleukin-10 activation of the interleukin-10E1 pathway and tissue inhibitor of metalloproteinase-1 expression is enhanced by proteasome inhibitors in primary prostate tumor lines. Stearns ME, et al. Mol Cancer Res, 2003 Jul. PMID 12861049.
IL-10/IL-10 receptor signaling regulates TIMP-1 expression in primary human prostate tumor lines. Wang M, et al. Cancer Biol Ther, 2002 Sep-Oct. PMID 12496489.
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932.
LIM-domain protein cysteine- and glycine-rich protein 2 (CRP2) is a novel marker of hepatic stellate cells and binding partner of the protein inhibitor of activated STAT1. Weiskirchen R, et al. Biochem J, 2001 Nov 1. PMID 11672422.
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