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Goat Anti-CSK Antibody

Peptide-affinity purified goat antibody

  • IHC - Goat Anti-CSK Antibody AF1280a
    AF1280a (4 µg/ml) staining of paraffin embedded Human Colon. Steamed antigen retrieval with citrate buffer pH 6, HRP-staining.
  • WB - Goat Anti-CSK Antibody AF1280a
    AF1280a (1 µg/ml) staining of Mouse Spleen lysate (35 µg protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.
  • WB - Goat Anti-CSK Antibody AF1280a
    EB5118 (0.5 µg/ml) staining of Jurkat lysate (35 µg protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession P41240
Other Accession NP_001120662, 1445, 12988 (mouse)
Reactivity Human, Mouse, Rat
Predicted Dog, Cow
Host Goat
Clonality Polyclonal
Concentration 100ug/200ul
Isotype IgG
Calculated MW 50704 Da
Additional Information
Gene ID 1445
Other Names Tyrosine-protein kinase CSK,, C-Src kinase, Protein-tyrosine kinase CYL, CSK
Format 0.5 mg IgG/ml in Tris saline (20mM Tris pH7.3, 150mM NaCl), 0.02% sodium azide, with 0.5% bovine serum albumin
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsGoat Anti-CSK Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name CSK
Function Non-receptor tyrosine-protein kinase that plays an important role in the regulation of cell growth, differentiation, migration and immune response. Phosphorylates tyrosine residues located in the C-terminal tails of Src-family kinases (SFKs) including LCK, SRC, HCK, FYN, LYN or YES1. Upon tail phosphorylation, Src-family members engage in intramolecular interactions between the phosphotyrosine tail and the SH2 domain that result in an inactive conformation. To inhibit SFKs, CSK is recruited to the plasma membrane via binding to transmembrane proteins or adapter proteins located near the plasma membrane. Suppresses signaling by various surface receptors, including T- cell receptor (TCR) and B-cell receptor (BCR) by phosphorylating and maintaining inactive several positive effectors such as FYN or LCK.
Cellular Location Cytoplasm. Cell membrane. Note=Mainly cytoplasmic, also present in lipid rafts.
Tissue Location Expressed in lung and macrophages.
Research Areas
Citations (0)

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Variation at the NFATC2 Locus Increases the Risk of Thiazolinedinedione-Induced Edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) Study. Bailey SD, et al. Diabetes Care, 2010 Jul 13. PMID 20628086.
Confirmation of top polymorphisms in hypertension genome wide association study among Han Chinese. Niu W, et al. Clin Chim Acta, 2010 Oct 9. PMID 20542020.
Blood pressure and hypertension are associated with 7 loci in the Japanese population. Takeuchi F, et al. Circulation, 2010 Jun 1. PMID 20479155.
A Large-scale genetic association study of esophageal adenocarcinoma risk. Liu CY, et al. Carcinogenesis, 2010 Jul. PMID 20453000.
Hydrophobic interaction between the SH2 domain and the kinase domain is required for the activation of Csk. Mikkola ET, et al. J Mol Biol, 2010 Jun 18. PMID 20434462.

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$ 325.00
Cat# AF1280a
(40 western blots)
Availability: 7-10 days
Bulk Size
Seasonal Special on Bulk Order
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