|Application ||WB, IHC, E|
|Other Accession||NP_000093, 1586|
|Calculated MW||57371 Da|
|Other Names||Steroid 17-alpha-hydroxylase/17, 20 lyase, 126.96.36.199, 188.8.131.52, 17-alpha-hydroxyprogesterone aldolase, CYPXVII, Cytochrome P450 17A1, Cytochrome P450-C17, Cytochrome P450c17, Steroid 17-alpha-monooxygenase, CYP17A1, CYP17, S17AH|
|Format||0.5 mg IgG/ml in Tris saline (20mM Tris pH7.3, 150mM NaCl), 0.02% sodium azide, with 0.5% bovine serum albumin|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||Goat Anti-CYP17A1 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Conversion of pregnenolone and progesterone to their 17- alpha-hydroxylated products and subsequently to dehydroepiandrosterone (DHEA) and androstenedione. Catalyzes both the 17-alpha-hydroxylation and the 17,20-lyase reaction. Involved in sexual development during fetal life and at puberty.|
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Provided below are standard protocols that you may find useful for product applications.
This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum. It has both 17alpha-hydroxylase and 17,20-lyase activities and is a key enzyme in the steroidogenic pathway that produces progestins, mineralocorticoids, glucocorticoids, androgens, and estrogens. Mutations in this gene are associated with isolated steroid-17 alpha-hydroxylase deficiency, 17-alpha-hydroxylase/17,20-lyase deficiency, pseudohermaphroditism, and adrenal hyperplasia.
The CYP17A1 -34T > C polymorphism and breast cancer risk in BRCA1 and BRCA2 mutation carriers. Kaufman B, et al. Breast Cancer Res Treat, 2010 Aug 27. PMID 20798986.
Genetic polymorphism of catechol-O-methyltransferase and cytochrome P450c17伪 in preeclampsia. Lim JH, et al. Pharmacogenet Genomics, 2010 Oct. PMID 20729792.
Betel quid chewing as an environmental risk factor for breast cancer. Kaushal M, et al. Mutat Res, 2010 Aug 20. PMID 20728566.
An approach based on a genome-wide association study reveals candidate loci for narcolepsy. Shimada M, et al. Hum Genet, 2010 Oct. PMID 20677014.
[Correlation between CYP17 gene polymorphisms and female postadolescent acne in Han population in Hunan Province.] Tian LM, et al. Nan Fang Yi Ke Da Xue Xue Bao, 2010 Jul. PMID 20650774.
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