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Goat Anti-CYP17A1 Antibody

Peptide-affinity purified goat antibody

  • WB - Goat Anti-CYP17A1 Antibody AF1292a
    AF1292a (0.3 µg/ml) staining of human ovary lysate (35 µg protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.
  • IHC - Goat Anti-CYP17A1 Antibody AF1292a
    AF1292a (3.8 µg/ml) staining of paraffin embedded Human Adrenal Gland. Steamed antigen retrieval with citrate buffer pH 6, AP-staining.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession P05093
Other Accession NP_000093, 1586
Reactivity Human
Predicted Dog, Cat
Host Goat
Clonality Polyclonal
Concentration 100ug/200ul
Isotype IgG
Calculated MW 57371 Da
Additional Information
Gene ID 1586
Other Names Steroid 17-alpha-hydroxylase/17, 20 lyase,,, 17-alpha-hydroxyprogesterone aldolase, CYPXVII, Cytochrome P450 17A1, Cytochrome P450-C17, Cytochrome P450c17, Steroid 17-alpha-monooxygenase, CYP17A1, CYP17, S17AH
Format 0.5 mg IgG/ml in Tris saline (20mM Tris pH7.3, 150mM NaCl), 0.02% sodium azide, with 0.5% bovine serum albumin
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsGoat Anti-CYP17A1 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name CYP17A1
Synonyms CYP17, S17AH
Function Conversion of pregnenolone and progesterone to their 17- alpha-hydroxylated products and subsequently to dehydroepiandrosterone (DHEA) and androstenedione. Catalyzes both the 17-alpha-hydroxylation and the 17,20-lyase reaction. Involved in sexual development during fetal life and at puberty.
Cellular Location Membrane.
Research Areas
Citations (0)

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This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum. It has both 17alpha-hydroxylase and 17,20-lyase activities and is a key enzyme in the steroidogenic pathway that produces progestins, mineralocorticoids, glucocorticoids, androgens, and estrogens. Mutations in this gene are associated with isolated steroid-17 alpha-hydroxylase deficiency, 17-alpha-hydroxylase/17,20-lyase deficiency, pseudohermaphroditism, and adrenal hyperplasia.


The CYP17A1 -34T > C polymorphism and breast cancer risk in BRCA1 and BRCA2 mutation carriers. Kaufman B, et al. Breast Cancer Res Treat, 2010 Aug 27. PMID 20798986.
Genetic polymorphism of catechol-O-methyltransferase and cytochrome P450c17伪 in preeclampsia. Lim JH, et al. Pharmacogenet Genomics, 2010 Oct. PMID 20729792.
Betel quid chewing as an environmental risk factor for breast cancer. Kaushal M, et al. Mutat Res, 2010 Aug 20. PMID 20728566.
An approach based on a genome-wide association study reveals candidate loci for narcolepsy. Shimada M, et al. Hum Genet, 2010 Oct. PMID 20677014.
[Correlation between CYP17 gene polymorphisms and female postadolescent acne in Han population in Hunan Province.] Tian LM, et al. Nan Fang Yi Ke Da Xue Xue Bao, 2010 Jul. PMID 20650774.

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$ 325.00
Cat# AF1292a
(40 western blots)
Availability: 7-10 days
Bulk Size
Seasonal Special on Bulk Order
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