|Application ||WB, E|
|Other Accession||NP_004388, 1656|
|Predicted||Mouse, Rat, Dog|
|Calculated MW||54417 Da|
|Other Names||Probable ATP-dependent RNA helicase DDX6, 188.8.131.52, ATP-dependent RNA helicase p54, DEAD box protein 6, Oncogene RCK, DDX6, HLR2, RCK|
|Format||0.5 mg IgG/ml in Tris saline (20mM Tris pH7.3, 150mM NaCl), 0.02% sodium azide, with 0.5% bovine serum albumin|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||Goat Anti-DEAD-box protein 6 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||In the process of mRNA degradation, plays a role in mRNA decapping (PubMed:16364915). Blocks autophagy in nutrient-rich conditions by repressing the expression of ATG-related genes through degration of their transcripts (PubMed:26098573).|
|Cellular Location||Cytoplasm, P-body. Cytoplasm. Nucleus. Note=Upon cellular stress, relocalizes to stress granules (PubMed:26184334)|
|Tissue Location||Abundantly expressed in most tissues.|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
email@example.com, and receive a free "I Love Antibodies" mug.
Provided below are standard protocols that you may find useful for product applications.
This gene encodes a member of the DEAD box protein family. The protein is an RNA helicase found in P-bodies and stress granules, and functions in translation suppression and mRNA degradation. It is required for microRNA-induced gene silencing.
DDX6 (Rck/p54) is required for efficient hepatitis C virus replication but not for internal ribosome entry site-directed translation. Jangra RK, et al. J Virol, 2010 Jul. PMID 20392846.
A genomewide association study of nicotine and alcohol dependence in Australian and Dutch populations. Lind PA, et al. Twin Res Hum Genet, 2010 Feb. PMID 20158304.
Genome-wide association study in a Chinese Han population identifies nine new susceptibility loci for systemic lupus erythematosus. Han JW, et al. Nat Genet, 2009 Nov. PMID 19838193.
Role of p54 RNA helicase activity and its C-terminal domain in translational repression, P-body localization and assembly. Minshall N, et al. Mol Biol Cell, 2009 May. PMID 19297524.
Structural basis for the mutually exclusive anchoring of P body components EDC3 and Tral to the DEAD box protein DDX6/Me31B. Tritschler F, et al. Mol Cell, 2009 Mar 13. PMID 19285948.
If you have used an Abgent product and would like to share how it has performed, please click on the "Submit Review" button and provide the requested information. Our staff will examine and post your review and contact you if needed.
If you have any additional inquiries please email technical services at firstname.lastname@example.org.