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Goat Anti-Desmin Antibody

Peptide-affinity purified goat antibody

     
  • WB - Goat Anti-Desmin Antibody AF1314a
    AF1314a (0.1 µg/ml) staining of Human Skeletal Muscle lysate (35 µg protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.
  • IHC - Goat Anti-Desmin Antibody AF1314a
    AF1314a (3.8 µg/ml) staining of paraffin embedded Human Prostate. Steamed antigen retrieval with citrate buffer pH 6, AP-staining.
  • SPECIFICATION
  • CITATIONS
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC, E
Primary Accession P17661
Other Accession NP_001918, 1674, 13346 (mouse), 64362 (rat)
Reactivity Human, Mouse, Rat, Pig
Predicted Dog, Cow
Host Goat
Clonality Polyclonal
Concentration 100ug/200ul
Isotype IgG
Calculated MW 53536 Da
Additional Information
Gene ID 1674
Other Names Desmin, DES
Format 0.5 mg IgG/ml in Tris saline (20mM Tris pH7.3, 150mM NaCl), 0.02% sodium azide, with 0.5% bovine serum albumin
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsGoat Anti-Desmin Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name DES
Function Desmin are class-III intermediate filaments found in muscle cells. In adult striated muscle they form a fibrous network connecting myofibrils to each other and to the plasma membrane from the periphery of the Z-line structures.
Cellular Location Cytoplasm. Cell membrane, sarcolemma
Research Areas
Citations (0)

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Background

This gene encodes a muscle-specific class III intermediate filament. Homopolymers of this protein form a stable intracytoplasmic filamentous network connecting myofibrils to each other and to the plasma membrane. Mutations in this gene are associated with desmin-related myopathy, a familial cardiac and skeletal myopathy (CSM), and with distal myopathies.

References

Desmin-related myopathy: a review and meta-analysis. van Spaendonck-Zwarts K, et al. Clin Genet, 2010 Jul 21. PMID 20718792.
Variation at the NFATC2 Locus Increases the Risk of Thiazolinedinedione-Induced Edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) Study. Bailey SD, et al. Diabetes Care, 2010 Jul 13. PMID 20628086.
A novel custom resequencing array for dilated cardiomyopathy. Zimmerman RS, et al. Genet Med, 2010 May. PMID 20474083.
Divergent molecular effects of desmin mutations on protein assembly in myofibrillar myopathy. Levin J, et al. J Neuropathol Exp Neurol, 2010 Apr. PMID 20448486.
Mutations in desmin's carboxy-terminal tail domain severely modify filament and network mechanics. B脌r H, et al. J Mol Biol, 2010 Apr 16. PMID 20171226.

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$ 335.00
Cat# AF1314a
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