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Goat Anti-DIO2 Antibody

Peptide-affinity purified goat antibody

  • IHC - Goat Anti-DIO2 Antibody AF1319a
    AF1319a (2 µg/ml) staining of PFA-fixed cryo-sectioned Mouse Hippocampus. Microwaved antigen retrieval with citrate buffer pH 4.5, HRP-staining.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q92813
Other Accession NP_001007024, 1734, 13371 (mouse), 65162 (rat)
Reactivity Mouse
Predicted Human, Rat, Pig
Host Goat
Clonality Polyclonal
Concentration 100ug/200ul
Isotype IgG
Calculated MW 30552 Da
Additional Information
Gene ID 1734
Other Names Type II iodothyronine deiodinase,, 5DII, DIOII, Type 2 DI, Type-II 5'-deiodinase, DIO2, ITDI2, TXDI2
Format 0.5 mg IgG/ml in Tris saline (20mM Tris pH7.3, 150mM NaCl), 0.02% sodium azide, with 0.5% bovine serum albumin
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsGoat Anti-DIO2 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name DIO2
Synonyms ITDI2, TXDI2
Function Responsible for the deiodination of T4 (3,5,3',5'- tetraiodothyronine) into T3 (3,5,3'-triiodothyronine). Essential for providing the brain with appropriate levels of T3 during the critical period of development.
Cellular Location Membrane; Single-pass membrane protein
Tissue Location Heart, skeletal muscle, placenta, fetal brain and several regions of the adult brain
Research Areas
Citations (0)

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The protein encoded by this gene belongs to the iodothyronine deiodinase family. It activates thyroid hormone by converting the prohormone thyroxine (T4) by outer ring deiodination (ORD) to bioactive 3,3',5-triiodothyronine (T3). It is highly expressed in the thyroid, and may contribute significantly to the relative increase in thyroidal T3 production in patients with Graves disease and thyroid adenomas. This protein contains selenocysteine (Sec) residues encoded by the UGA codon, which normally signals translation termination. The 3' UTR of Sec-containing genes have a common stem-loop structure, the sec insertion sequence (SECIS), which is necessary for the recognition of UGA as a Sec codon rather than as a stop signal. Alternative splicing results in multiple transcript variants encoding different isoforms.


Association of the type 2 deiodinase Thr92Ala polymorphism with type 2 diabetes: case-control study and meta-analysis. Dora JM, et al. Eur J Endocrinol, 2010 Sep. PMID 20566590.
Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. Rose JE, et al. Mol Med, 2010 Jul-Aug. PMID 20379614.
Regional decrease of subcutaneous adipose tissue in patients with type 2 familial partial lipodystrophy is associated with changes in thyroid hormone metabolism. Lado-Abeal J, et al. Thyroid, 2010 Apr. PMID 20373986.
The type 2 deiodinase Thr92Ala polymorphism is associated with increased bone turnover and decreased femoral neck bone mineral density. Heemstra KA, et al. J Bone Miner Res, 2010 Jun. PMID 20200941.
Association study between polymorphisms in selenoprotein genes and susceptibility to Kashin-Beck disease. Xiong YM, et al. Osteoarthritis Cartilage, 2010 Jun. PMID 20178852.

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$ 325.00
Cat# AF1319a
(40 western blots)
Availability: 7-10 days
Bulk Size
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