|Application ||WB, E|
|Other Accession||NP_004078, 1739|
|Calculated MW||100455 Da|
|Other Names||Disks large homolog 1, Synapse-associated protein 97, SAP-97, SAP97, hDlg, DLG1|
|Format||0.5 mg IgG/ml in Tris saline (20mM Tris pH7.3, 150mM NaCl), 0.02% sodium azide, with 0.5% bovine serum albumin|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||Goat Anti-DLG1 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Essential multidomain scaffolding protein required for normal development (By similarity). Recruits channels, receptors and signaling molecules to discrete plasma membrane domains in polarized cells. May play a role in adherens junction assembly, signal transduction, cell proliferation, synaptogenesis and lymphocyte activation. Regulates the excitability of cardiac myocytes by modulating the functional expression of Kv4 channels. Functional regulator of Kv1.5 channel.|
|Cellular Location||Membrane; Peripheral membrane protein. Basolateral cell membrane Endoplasmic reticulum membrane. Cell junction, synapse, postsynaptic cell membrane, postsynaptic density. Cell junction, synapse. Cell membrane, sarcolemma Note=Colocalizes with EPB41 at regions of intercellular contacts Basolateral in epithelial cells. May also associate with endoplasmic reticulum membranes. Mainly found in neurons soma, moderately found at postsynaptic densities (By similarity)|
|Tissue Location||Abundantly expressed in atrial myocardium (at protein level). Expressed in lung fibroblasts, cervical epithelial and B-cells (at protein level). Widely expressed, with isoforms displaying different expression profiles|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Microdeletions of 3q29 confer high risk for schizophrenia. Mulle JG, et al. Am J Hum Genet, 2010 Aug 13. PMID 20691406.
ERK5 pathway regulates the phosphorylation of tumour suppressor hDlg during mitosis. I帽esta-Vaquera FA, et al. Biochem Biophys Res Commun, 2010 Aug 13. PMID 20643107.
Ezrin tunes T-cell activation by controlling Dlg1 and microtubule positioning at the immunological synapse. Lasserre R, et al. EMBO J, 2010 Jul 21. PMID 20551903.
Comprehensive copy number variant (CNV) analysis of neuronal pathways genes in psychiatric disorders identifies rare variants within patients. Saus E, et al. J Psychiatr Res, 2010 Apr 14. PMID 20398908.
Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. Rose JE, et al. Mol Med, 2010 Jul-Aug. PMID 20379614.
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