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Goat Anti-Dynactin Antibody

Peptide-affinity purified goat antibody

  • WB - Goat Anti-Dynactin Antibody AF1347a
    AF1347a staining (1 µg/ml) of Human Testis lysate (RIPA buffer, 35 µg total protein per lane). Primary incubated for 1 hour. Detected by western blot using chemiluminescence.
  • IHC - Goat Anti-Dynactin Antibody AF1347a
    AF1347a (2.5 µg/ml) staining of paraffin embedded Human Cerebellum. Steamed antigen retrieval with citrate buffer pH 6, AP-staining.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q14203
Other Accession NP_001128513, 1639, 13191 (mouse)
Reactivity Human, Mouse
Predicted Rat
Host Goat
Clonality Polyclonal
Concentration 0.5 mg/ml
Isotype IgG
Calculated MW 141695 Da
Additional Information
Gene ID 1639
Other Names Dynactin subunit 1, 150 kDa dynein-associated polypeptide, DAP-150, DP-150, p135, p150-glued, DCTN1
Format 0.5 mg IgG/ml in Tris saline (20mM Tris pH7.3, 150mM NaCl), 0.02% sodium azide, with 0.5% bovine serum albumin
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsGoat Anti-Dynactin Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name DCTN1
Function Required for the cytoplasmic dynein-driven retrograde movement of vesicles and organelles along microtubules. Dynein- dynactin interaction is a key component of the mechanism of axonal transport of vesicles and organelles.
Cellular Location Cytoplasm. Cytoplasm, cytoskeleton Note=Colocalizes with microtubules
Tissue Location Brain.
Research Areas
Citations (0)

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This gene encodes the largest subunit of dynactin, a macromolecular complex consisting of 10 subunits ranging in size from 22 to 150 kD. Dynactin binds to both microtubules and cytoplasmic dynein. Dynactin is involved in a diverse array of cellular functions, including ER-to-Golgi transport, the centripetal movement of lysosomes and endosomes, spindle formation, chromosome movement, nuclear positioning, and axonogenesis. This subunit interacts with dynein intermediate chain by its domains directly binding to dynein and binds to microtubules via a highly conserved glycine-rich cytoskeleton-associated protein (CAP-Gly) domain in its N-terminus. Alternative splicing of this gene results in multiple transcript variants encoding distinct isoforms. Mutations in this gene cause distal hereditary motor neuronopathy type VIIB (HMN7B) which is also known as distal spinal and bulbar muscular atrophy (dSBMA).


Disease-associated mutations in the p150(Glued) subunit destabilize the CAP-gly domain. Ahmed S, et al. Biochemistry, 2010 Jun 29. PMID 20518521.
Centrosome-related genes, genetic variation, and risk of breast cancer. Olson JE, et al. Breast Cancer Res Treat, 2010 May 28. PMID 20508983.
The retromer component SNX6 interacts with dynactin p150(Glued) and mediates endosome-to-TGN transport. Hong Z, et al. Cell Res, 2009 Dec. PMID 19935774.
Dynactin subunit p150Glued isoforms notable for differential interaction with microtubules. Zhapparova ON, et al. Traffic, 2009 Nov. PMID 19778315.
Cholesterol sensor ORP1L contacts the ER protein VAP to control Rab7-RILP-p150 Glued and late endosome positioning. Rocha N, et al. J Cell Biol, 2009 Jun 29. PMID 19564404.

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$ 325.00
Cat# AF1347a
(40 western blots)
Availability: 7-10 days
Bulk Size
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