|Application ||WB, IHC, E|
|Other Accession||NP_000390, 1959, 13654 (mouse), 114090 (rat)|
|Predicted||Mouse, Rat, Dog|
|Calculated MW||50302 Da|
|Other Names||E3 SUMO-protein ligase EGR2, 6.3.2.-, AT591, Early growth response protein 2, EGR-2, Zinc finger protein Krox-20, EGR2, KROX20|
|Format||0.5 mg IgG/ml in Tris saline (20mM Tris pH7.3, 150mM NaCl), 0.02% sodium azide, with 0.5% bovine serum albumin|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||Goat Anti-EGR2 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Sequence-specific DNA-binding transcription factor. Binds to two specific DNA sites located in the promoter region of HOXA4.|
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Provided below are standard protocols that you may find useful for product applications.
The protein encoded by this gene is a transcription factor with three tandem C2H2-type zinc fingers. Defects in this gene are associated with Charcot-Marie-Tooth disease type 1D (CMT1D), Charcot-Marie-Tooth disease type 4E (CMT4E), and with Dejerine-Sottas syndrome (DSS). Multiple transcript variants encoding two different isoforms have been found for this gene.
EGR3 as a potential susceptibility gene for schizophrenia in Korea. Kim SH, et al. Am J Med Genet B Neuropsychiatr Genet, 2010 Aug 4. PMID 20687139.
Evaluation of candidate stromal epithelial cross-talk genes identifies association between risk of serous ovarian cancer and TERT, a cancer susceptibility hot-spot. Johnatty SE, et al. PLoS Genet, 2010 Jul 8. PMID 20628624.
Adult onset Charcot-Marie-Tooth disease type 1D with an Arg381Cys mutation of EGR2. Briani C, et al. Muscle Nerve, 2010 Jun. PMID 20513111.
Biological Pathway-Based Genome-Wide Association Analysis Identified the Vasoactive Intestinal Peptide (VIP) Pathway Important for Obesity. Liu YJ, et al. Obesity (Silver Spring), 2010 Apr 8. PMID 20379146.
Regulatory polymorphisms in EGR2 are associated with susceptibility to systemic lupus erythematosus. Myouzen K, et al. Hum Mol Genet, 2010 Jun 1. PMID 20194224.
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