Goat Anti-EndoPDI / TXNDC5 Antibody
Peptide-affinity purified goat antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| WB, E |
---|---|
Primary Accession | Q8NBS9 |
Other Accession | NP_001139021, 81567 |
Reactivity | Human |
Host | Goat |
Clonality | Polyclonal |
Concentration | 100ug/200ul |
Isotype | IgG |
Calculated MW | 47629 Da |
Gene ID | 81567 |
---|---|
Other Names | Thioredoxin domain-containing protein 5, Endoplasmic reticulum resident protein 46, ER protein 46, ERp46, Thioredoxin-like protein p46, TXNDC5, TLP46 |
Format | 0.5 mg IgG/ml in Tris saline (20mM Tris pH7.3, 150mM NaCl), 0.02% sodium azide, with 0.5% bovine serum albumin |
Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
Precautions | Goat Anti-EndoPDI / TXNDC5 Antibody is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | TXNDC5 (HGNC:21073) |
---|---|
Synonyms | TLP46 |
Function | Protein disulfide isomerase of the endoplasmic reticulum lumen involved in the formation of disulfide bonds in proteins. Can reduce insulin disulfide bonds. |
Cellular Location | Endoplasmic reticulum lumen {ECO:0000250|UniProtKB:Q91W90, ECO:0000255|PROSITE-ProRule:PRU10138} |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
info@abcepta.com, and receive a free "I Love Antibodies" mug.
Provided below are standard protocols that you may find useful for product applications.
Background
This gene encodes a protein-disulfide isomerase. Its expression is induced by hypoxia and its role may be to protect hypoxic cells from apoptosis. Two transcript variants encoding different isoforms have been found for this gene.
References
The influence of TXNDC5 gene on gastric cancer cell. Zhang L, et al. J Cancer Res Clin Oncol, 2010 Oct. PMID 20157732.
ERp46 binds to AdipoR1, but not AdipoR2, and modulates adiponectin signalling. Charlton HK, et al. Biochem Biophys Res Commun, 2010 Feb 5. PMID 20074551.
Association of TXNDC5 gene polymorphisms and susceptibility to nonsegmental vitiligo in the Korean population. Jeong KH, et al. Br J Dermatol, 2010 Apr. PMID 19906073.
Protein disulphide isomerase family members show distinct substrate specificity: P5 is targeted to BiP client proteins. Jessop CE, et al. J Cell Sci, 2009 Dec 1. PMID 19887585.
Sequential use of transcriptional profiling, expression quantitative trait mapping, and gene association implicates MMP20 in human kidney aging. Wheeler HE, et al. PLoS Genet, 2009 Oct. PMID 19834535.
If you have used an Abcepta product and would like to share how it has performed, please click on the "Submit Review" button and provide the requested information. Our staff will examine and post your review and contact you if needed.
If you have any additional inquiries please email technical services at tech@abcepta.com.