|Application ||WB, E|
|Other Accession||NP_006808, 10961, 67397 (mouse), 117030 (rat)|
|Predicted||Rat, Pig, Dog, Cow|
|Calculated MW||28993 Da|
|Other Names||Endoplasmic reticulum resident protein 29, ERp29, Endoplasmic reticulum resident protein 28, ERp28, Endoplasmic reticulum resident protein 31, ERp31, ERP29, C12orf8, ERP28|
|Format||0.5 mg IgG/ml in Tris saline (20mM Tris pH7.3, 150mM NaCl), 0.02% sodium azide, with 0.5% bovine serum albumin|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||Goat Anti-ERP29 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Does not seem to be a disulfide isomerase. Plays an important role in the processing of secretory proteins within the endoplasmic reticulum (ER), possibly by participating in the folding of proteins in the ER.|
|Cellular Location||Endoplasmic reticulum lumen. Melanosome. Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV|
|Tissue Location||Ubiquitous. Mostly expressed in secretory tissues|
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Provided below are standard protocols that you may find useful for product applications.
This gene encodes a reticuloplasmin, a protein which resides in the lumen of the endoplasmic reticulum (ER). The protein shows sequence similarity to the protein disulfide isomerase family. However, it lacks the thioredoxin motif characteristic of this family, suggesting that this protein does not function as a disulfide isomerase. The protein dimerizes and is thought to play a role in the processing of secretory proteins within the ER. Alternative splicing results in multiple transcript variants encoding different isoforms.
Overexpression of endoplasmic reticulum protein 29 regulates mesenchymal-epithelial transition and suppresses xenograft tumor growth of invasive breast cancer cells. Bambang IF, et al. Lab Invest, 2009 Nov. PMID 19770839.
ERp29 restricts Connexin43 oligomerization in the endoplasmic reticulum. Das S, et al. Mol Biol Cell, 2009 May. PMID 19321666.
Cytokeratin 19 regulates endoplasmic reticulum stress and inhibits ERp29 expression via p38 MAPK/XBP-1 signaling in breast cancer cells. Bambang IF, et al. Exp Cell Res, 2009 Jul 1. PMID 19265690.
Crystal structure and functional analysis of the protein disulfide isomerase-related protein ERp29. Barak NN, et al. J Mol Biol, 2009 Feb 6. PMID 19084538.
ERp29, an endoplasmic reticulum secretion factor is involved in the growth of breast tumor xenografts. Mkrtchian S, et al. Mol Carcinog, 2008 Nov. PMID 18395818.
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