|Application ||WB, IHC, E|
|Other Accession||NP_056034, 23265|
|Predicted||Mouse, Rat, Pig, Cow|
|Calculated MW||83382 Da|
|Other Names||Exocyst complex component 7, Exocyst complex component Exo70, EXOC7, EXO70, KIAA1067|
|Format||0.5 mg IgG/ml in Tris saline (20mM Tris pH7.3, 150mM NaCl), 0.02% sodium azide, with 0.5% bovine serum albumin|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||Goat Anti-EXOC7 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane. In adipocytes, plays a crucial role in targeting SLC2A4 vesicle to the plasma membrane in response to insulin, perhaps directing the vesicle to the precise site of fusion (By similarity).|
|Cellular Location||Cytoplasm, cytosol. Cell membrane; Peripheral membrane protein Note=Translocates, as a preformed complex with SEC6 and SEC8, to the plasma membrane in response to insulin through the activation of ARHQ.|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
EXOC7 is a component of the exocyst, which is an evolutionarily conserved octameric protein complex essential for exocytosis. The exocyst targets secretory vesicles at specific domains of the plasma membrane for cell surface expansion and protein secretion (Zuo et al., 2006 [PubMed 17086175]).
Novel interaction partners of Bardet-Biedl syndrome proteins. Oeffner F, et al. Cell Motil Cytoskeleton, 2008 Feb. PMID 18000879.
Exo70 interacts with the Arp2/3 complex and regulates cell migration. Zuo X, et al. Nat Cell Biol, 2006 Dec. PMID 17086175.
A probability-based approach for high-throughput protein phosphorylation analysis and site localization. Beausoleil SA, et al. Nat Biotechnol, 2006 Oct. PMID 16964243.
Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. Kimura K, et al. Genome Res, 2006 Jan. PMID 16344560.
Towards a proteome-scale map of the human protein-protein interaction network. Rual JF, et al. Nature, 2005 Oct 20. PMID 16189514.
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