|Application ||WB, E|
|Other Accession||NP_005114, 9971|
|Calculated MW||55914 Da|
|Other Names||Bile acid receptor, Farnesoid X-activated receptor, Farnesol receptor HRR-1, Nuclear receptor subfamily 1 group H member 4, Retinoid X receptor-interacting protein 14, RXR-interacting protein 14, NR1H4, BAR, FXR, HRR1, RIP14|
|Format||0.5 mg IgG/ml in Tris saline (20mM Tris pH7.3, 150mM NaCl), 0.02% sodium azide, with 0.5% bovine serum albumin|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||Goat Anti-Farnesoid X receptor / FXR Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Synonyms||BAR, FXR, HRR1, RIP14|
|Function||Ligand-activated transcription factor. Receptor for bile acids such as chenodeoxycholic acid, lithocholic acid and deoxycholic acid. Represses the transcription of the cholesterol 7-alpha-hydroxylase gene (CYP7A1) through the induction of NR0B2 or FGF19 expression, via two distinct mechanisms. Activates the intestinal bile acid-binding protein (IBABP). Activates the transcription of bile salt export pump ABCB11 by directly recruiting histone methyltransferase CARM1 to this locus.|
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Provided below are standard protocols that you may find useful for product applications.
The nuclear receptor FXR is expressed in pancreatic beta-cells and protects human islets from lipotoxicity. Popescu IR, et al. FEBS Lett, 2010 Jul 2. PMID 20447400.
Bile acids and their nuclear receptor FXR: Relevance for hepatobiliary and gastrointestinal disease. Gadaleta RM, et al. Biochim Biophys Acta, 2010 Jul. PMID 20399894.
Genetic risk factors for hepatopulmonary syndrome in patients with advanced liver disease. Roberts KE, et al. Gastroenterology, 2010 Jul. PMID 20346360.
Regulation of the human bile acid UDP-glucuronosyltransferase 1A3 by the farnesoid X receptor and bile acids. Erichsen TJ, et al. J Hepatol, 2010 Apr. PMID 20189675.
Farnesoid X receptor, through the binding with steroidogenic factor 1-responsive element, inhibits aromatase expression in tumor Leydig cells. Catalano S, et al. J Biol Chem, 2010 Feb 19. PMID 20026603.
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