|Application ||WB, E|
|Other Accession||NP_055198, 27033|
|Calculated MW||52963 Da|
|Other Names||Zinc finger and BTB domain-containing protein 32, FANCC-interacting protein, Fanconi anemia zinc finger protein, Testis zinc finger protein, Zinc finger protein 538, ZBTB32, FAZF, TZFP, ZNF538|
|Format||0.5 mg IgG/ml in Tris saline (20mM Tris pH7.3, 150mM NaCl), 0.02% sodium azide, with 0.5% bovine serum albumin|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||Goat Anti-FAZF / TZFP / ZBTB32 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Synonyms||FAZF, TZFP, ZNF538|
|Function||DNA-binding protein that binds to the to a 5'- TGTACAGTGT-3' core sequence. May function as a transcriptional transactivator and transcriptional repressor. Probably exerts its repressor effect by preventing GATA3 from binding to DNA. May play a role in regulating the differentiation and activation of helper T-cells (By similarity).|
|Cellular Location||Nucleus. Note=Located in nuclear speckles|
|Tissue Location||Predominantly expressed in testis. Some isoforms are ubiquitously expressed|
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Provided below are standard protocols that you may find useful for product applications.
Insights into strand exchange in BTB domain dimers from the crystal structures of FAZF and Miz1. Stogios PJ, et al. J Mol Biol, 2010 Jul 30. PMID 20493880.
Human endogenous retrovirus protein Rec interacts with the testicular zinc-finger protein and androgen receptor. Kaufmann S, et al. J Gen Virol, 2010 Jun. PMID 20147518.
Shifted Transversal Design smart-pooling for high coverage interactome mapping. Xin X, et al. Genome Res, 2009 Jul. PMID 19447967.
A UAF1-containing multisubunit protein complex regulates the Fanconi anemia pathway. Cohn MA, et al. Mol Cell, 2007 Dec 14. PMID 18082604.
Identification of FAZF as a novel BMP2-induced transcription factor during osteoblastic differentiation. Ikeda R, et al. J Cell Biochem, 2007 May 1. PMID 17171645.
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