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Goat Anti-FEZ1 / Zygin 1 Antibody

Peptide-affinity purified goat antibody

  • WB - Goat Anti-FEZ1 / Zygin 1 Antibody AF1409a
    AF1409a (0.03 µg/ml) staining of Human Brain (frontal Cortex) lysate (35 µg protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q99689
Other Accession NP_005094, 9638, 235180 (mouse), 81730 (rat)
Reactivity Human
Predicted Mouse, Rat, Dog
Host Goat
Clonality Polyclonal
Concentration 100ug/200ul
Isotype IgG
Calculated MW 45119 Da
Additional Information
Gene ID 9638
Other Names Fasciculation and elongation protein zeta-1, Zygin I, Zygin-1, FEZ1
Format 0.5 mg IgG/ml in Tris saline (20mM Tris pH7.3, 150mM NaCl), 0.02% sodium azide, with 0.5% bovine serum albumin
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsGoat Anti-FEZ1 / Zygin 1 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name FEZ1
Function May be involved in axonal outgrowth as component of the network of molecules that regulate cellular morphology and axon guidance machinery. Able to restore partial locomotion and axonal fasciculation to C.elegans unc-76 mutants in germline transformation experiments. May participate in the transport of mitochondria and other cargos along microtubules.
Cellular Location Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cell membrane. Note=Colocalizes with both, alpha- and gamma-tubulin. Translocated from the plasma membrane to the cytoplasm by activation of the PKC zeta (By similarity)
Tissue Location Mainly expressed in brain.
Research Areas
Citations (0)

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This gene is an ortholog of the C. elegans unc-76 gene, which is necessary for normal axonal bundling and elongation within axon bundles. Expression of this gene in C. elegans unc-76 mutants can restore to the mutants partial locomotion and axonal fasciculation, suggesting that it also functions in axonal outgrowth. The N-terminal half of the gene product is highly acidic. Alternatively spliced transcript variants encoding different isoforms of this protein have been described.


Evidence of statistical epistasis between DISC1, CIT and NDEL1 impacting risk for schizophrenia: biological validation with functional neuroimaging. Nicodemus KK, et al. Hum Genet, 2010 Jan 19. PMID 20084519.
The brain-specific factor FEZ1 is a determinant of neuronal susceptibility to HIV-1 infection. Haedicke J, et al. Proc Natl Acad Sci U S A, 2009 Aug 18. PMID 19667186.
Genetic association and post-mortem brain mRNA analysis of DISC1 and related genes in schizophrenia. Rastogi A, et al. Schizophr Res, 2009 Oct. PMID 19632097.
Identification of neuroglycan C and interacting partners as potential susceptibility genes for schizophrenia in a Southern Chinese population. So HC, et al. Am J Med Genet B Neuropsychiatr Genet, 2010 Jan 5. PMID 19367581.
Association between genes of Disrupted in schizophrenia 1 (DISC1) interactors and schizophrenia supports the role of the DISC1 pathway in the etiology of major mental illnesses. Tomppo L, et al. Biol Psychiatry, 2009 Jun 15. PMID 19251251.

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$ 325.00
Cat# AF1409a
(40 western blots)
Availability: 7-10 days
Bulk Size
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