|Application ||WB, E|
|Other Accession||NP_001441, 2274, 14200 (mouse), 63839 (rat)|
|Predicted||Rat, Dog, Cow|
|Calculated MW||32193 Da|
|Other Names||Four and a half LIM domains protein 2, FHL-2, LIM domain protein DRAL, Skeletal muscle LIM-protein 3, SLIM-3, FHL2, DRAL, SLIM3|
|Format||0.5 mg IgG/ml in Tris saline (20mM Tris pH7.3, 150mM NaCl), 0.02% sodium azide, with 0.5% bovine serum albumin|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||Goat Anti-FHL2 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||May function as a molecular transmitter linking various signaling pathways to transcriptional regulation. Negatively regulates the transcriptional repressor E4F1 and may function in cell growth. Inhibits the transcriptional activity of FOXO1 and its apoptotic function by enhancing the interaction of FOXO1 with SIRT1 and FOXO1 deacetylation.|
|Cellular Location||Cytoplasm. Nucleus.|
|Tissue Location||Expressed in skeletal muscle and heart.|
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Provided below are standard protocols that you may find useful for product applications.
LIM proteins contain a highly conserved double zinc finger motif called the LIM domain.
Sp1 upregulates the four and half lim 2 (FHL2) expression in gastrointestinal cancers through transcription regulation. Guo Z, et al. Mol Carcinog, 2010 Sep. PMID 20607723.
Four-and-a-half LIM domain protein 2 is a novel regulator of sphingosine 1-phosphate receptor 1 in CCL19-induced dendritic cell migration. K枚nig K, et al. J Immunol, 2010 Aug 1. PMID 20592280.
Four-and-a-half LIM protein 2 promotes invasive potential and epithelial-mesenchymal transition in colon cancer. Zhang W, et al. Carcinogenesis, 2010 Jul. PMID 20460358.
Four and a half LIM domain 2 alters the impact of aryl hydrocarbon receptor on androgen receptor transcriptional activity. Kollara A, et al. J Steroid Biochem Mol Biol, 2010 Jan. PMID 19815066.
The Patched dependence receptor triggers apoptosis through a DRAL-caspase-9 complex. Mille F, et al. Nat Cell Biol, 2009 Jun. PMID 19465923.
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