|Application ||WB, IHC, E|
|Other Accession||NP_005794, 10211, 14251 (mouse)|
|Predicted||Pig, Dog, Cow|
|Calculated MW||47355 Da|
|Other Names||Flotillin-1, FLOT1|
|Format||0.5 mg IgG/ml in Tris saline (20mM Tris pH7.3, 150mM NaCl), 0.02% sodium azide, with 0.5% bovine serum albumin|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||Goat Anti-Flotillin 1 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||May act as a scaffolding protein within caveolar membranes, functionally participating in formation of caveolae or caveolae-like vesicles.|
|Cellular Location||Cell membrane; Peripheral membrane protein. Membrane, caveola; Peripheral membrane protein. Melanosome Endosome. Note=Membrane-associated protein of caveolae. Identified by mass spectrometry in melanosome fractions from stage I to stage IV|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Caveolae are small domains on the inner cell membrane involved in vesicular trafficking and signal transduction. FLOT1 encodes a caveolae-associated, integral membrane protein. The function of flotillin 1 has not been determined.
Flotillins are involved in the polarization of primitive and mature hematopoietic cells. Rajendran L, et al. PLoS One, 2009 Dec 22. PMID 20027317.
High-density SNP screening of the major histocompatibility complex in systemic lupus erythematosus demonstrates strong evidence for independent susceptibility regions. Barcellos LF, et al. PLoS Genet, 2009 Oct. PMID 19851445.
The Mycobacterium bovis bacille Calmette-Guerin phagosome proteome. Lee BY, et al. Mol Cell Proteomics, 2010 Jan. PMID 19815536.
Flotillins interact with PSGL-1 in neutrophils and, upon stimulation, rapidly organize into membrane domains subsequently accumulating in the uropod. Rossy J, et al. PLoS One, 2009. PMID 19404397.
Protein delivery with transportans is mediated by caveolae rather than flotillin-dependent pathways. S脌脌lik P, et al. Bioconjug Chem, 2009 May 20. PMID 19348413.
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