|Application ||WB, E|
|Other Accession||NP_054772, 28982|
|Calculated MW||59863 Da|
|Other Names||Feline leukemia virus subgroup C receptor-related protein 1, Feline leukemia virus subgroup C receptor, hFLVCR, FLVCR1, FLVCR|
|Format||0.5 mg IgG/ml in Tris saline (20mM Tris pH7.3, 150mM NaCl), 0.02% sodium azide, with 0.5% bovine serum albumin|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||Goat Anti-FLVCR Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Isoform 1: Heme transporter that exports cytoplasmic heme. It can also export coproporphyrin and protoporphyrin IX, which are both intermediate products in the heme biosynthetic pathway. Does not export bilirubin. Heme export depends on the presence of HPX and may be required to protect developing erythroid cells from heme toxicity. Heme export also provides protection from heme or ferrous iron toxicities in liver and brain. Causes susceptibility to FeLV-C in vitro. Required during erythtopoiesis to maintain intracellular free heme balance since in proerythroblasts, heme synthesis intensifies and it's accumulation is toxic for cells.|
|Cellular Location||Isoform 1: Cell membrane; Multi-pass membrane protein|
|Tissue Location||Found all hematopoietic tissues including peripheral blood lymphocytes. Some expression is found in pancreas and kidney.|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Enhanced alternative splicing of the FLVCR1 gene in Diamond Blackfan anemia disrupts FLVCR1 expression and function that are critical for erythropoiesis. Rey MA, et al. Haematologica, 2008 Nov. PMID 18815190.
Comprehensive mapping of receptor-functioning domains in feline leukemia virus subgroup C receptor FLVCR1. Brown JK, et al. J Virol, 2006 Feb. PMID 16439531.
Genomic annotation of 15,809 ESTs identified from pooled early gestation human eyes. Choy KW, et al. Physiol Genomics, 2006 Mar 13. PMID 16368877.
Investigation of a putative role for FLVCR, a cytoplasmic heme exporter, in Diamond-Blackfan anemia. Quigley JG, et al. Blood Cells Mol Dis, 2005 Sep-Oct. PMID 15996880.
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Gerhard DS, et al. Genome Res, 2004 Oct. PMID 15489334.
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