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Goat Anti-FOXG1 / BF2 Antibody
Peptide-affinity purified goat antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, IF, ICC, E |
|---|---|
| Primary Accession | P55316 |
| Other Accession | NP_005240, 2290, 15228 (mouse), 24370 (rat) |
| Reactivity | Human, Mouse |
| Predicted | Rat, Dog, Cow |
| Host | Goat |
| Clonality | Polyclonal |
| Concentration | 100ug/200ul |
| Isotype | IgG |
| Calculated MW | 52352 Da |
| Gene ID | 2290 |
|---|---|
| Other Names | Forkhead box protein G1, Brain factor 1, BF-1, BF1, Brain factor 2, BF-2, BF2, hBF-2, Forkhead box protein G1A, Forkhead box protein G1B, Forkhead box protein G1C, Forkhead-related protein FKHL1, HFK1, Forkhead-related protein FKHL2, HFK2, Forkhead-related protein FKHL3, HFK3, FOXG1 |
| Format | 0.5 mg IgG/ml in Tris saline (20mM Tris pH7.3, 150mM NaCl), 0.02% sodium azide, with 0.5% bovine serum albumin |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | Goat Anti-FOXG1 / BF2 Antibody is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | FOXG1 |
|---|---|
| Function | Transcription repression factor which plays an important role in the establishment of the regional subdivision of the developing brain and in the development of the telencephalon. |
| Cellular Location | Nucleus {ECO:0000255|PROSITE-ProRule:PRU00089, ECO:0000269|PubMed:21280142} |
| Tissue Location | Expression is restricted to the neurons of the developing telencephalon. |
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Provided below are standard protocols that you may find useful for product applications.
Background
This gene belongs to the forkhead family of transcription factors which is characterized by a distinct forkhead domain. The specific function of this gene has not yet been determined; however, it may play a role in the development of the brain and telencephalon.
References
Epilepsy in Rett syndrome: Clinical and genetic features. Pintaudi M, et al. Epilepsy Behav, 2010 Aug 20. PMID 20728410.
Revisiting the phenotype associated with FOXG1 mutations: two novel cases of congenital Rett variant. Bahi-Buisson N, et al. Neurogenetics, 2010 May. PMID 19806373.
Novel FOXG1 mutations associated with the congenital variant of Rett syndrome. Mencarelli MA, et al. J Med Genet, 2010 Jan. PMID 19578037.
Phenotypic variability in Rett syndrome associated with FOXG1 mutations in females. Philippe C, et al. J Med Genet, 2010 Jan. PMID 19564653.
FOXG1 is responsible for the congenital variant of Rett syndrome. Ariani F, et al. Am J Hum Genet, 2008 Jul. PMID 18571142.
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