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Goat Anti-FOXL2 / BPES Antibody

Peptide-affinity purified goat antibody

  • IHC - Goat Anti-FOXL2 / BPES Antibody AF1432a
    AF1432a (2 µg/ml) staining of paraffin embedded Human Ovary. Steamed antigen retrieval with citrate buffer pH 6, AP-staining.
  • WB - Goat Anti-FOXL2 / BPES Antibody AF1432a
    AF1432a (0.5 µg/ml) staining of Human Ovary lysate (35 µg protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession P58012
Other Accession NP_075555, 668, 26927 (mouse)
Reactivity Human, Mouse
Predicted Rat, Cow
Host Goat
Clonality Polyclonal
Concentration 100ug/200ul
Isotype IgG
Calculated MW 38772 Da
Additional Information
Gene ID 668
Other Names Forkhead box protein L2, FOXL2
Format 0.5 mg IgG/ml in Tris saline (20mM Tris pH7.3, 150mM NaCl), 0.02% sodium azide, with 0.5% bovine serum albumin
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsGoat Anti-FOXL2 / BPES Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name FOXL2
Function Transcriptional regulator. Critical factor essential for ovary differentiation and maintenance, and repression of the genetic program for somatic testis determination. Prevents trans- differentiation of ovary to testis through transcriptional repression of the Sertoli cell-promoting gene SOX9 (By similarity). Has apoptotic activity in ovarian cells. Suppresses ESR1-mediated transcription of PTGS2/COX2 stimulated by tamoxifen (By similarity). Is a regulator of CYP19 expression (By similarity). Participates in SMAD3-dependent transcription of FST via the intronic SMAD-binding element (By similarity). Is a transcriptional repressor of STAR. Activates SIRT1 transcription under cellular stress conditions. Activates transcription of OSR2.
Cellular Location Nucleus {ECO:0000255|PROSITE- ProRule:PRU00089, ECO:0000269|PubMed:19744555}
Tissue Location In addition to its expression in the developing eyelid, it is transcribed very early in somatic cells of the developing gonad (before sex determination) and its expression persists in the follicular cells of the adult ovary
Research Areas
Citations (0)

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This gene encodes a forkhead transcription factor. The protein contains a fork-head DNA-binding domain and may play a role in ovarian development and function. Mutations in this gene are a cause of blepharophimosis syndrome and premature ovarian failure 3.


FOXL2 mutation in granulosa-cell tumours of the ovary. Kim T, et al. Histopathology, 2010 Feb. PMID 20459545.
Revisiting reproduction: What a difference a gene makes. Murphy BD. Nat Med, 2010 May. PMID 20448577.
FoxL2 Is required for activin induction of the mouse and human follicle-stimulating hormone beta-subunit genes. Corpuz PS, et al. Mol Endocrinol, 2010 May. PMID 20233786.
Mutation analysis of FOXL2 gene in Chinese patients with premature ovarian failure. Ni F, et al. Gynecol Endocrinol, 2010 Apr. PMID 20222838.
FOXL2 interacts with steroidogenic factor-1 (SF-1) and represses SF-1-induced CYP17 transcription in granulosa cells. Park M, et al. Mol Endocrinol, 2010 May. PMID 20207836.

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$ 325.00
Cat# AF1432a
(40 western blots)
Availability: 7-10 days
Bulk Size
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