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Goat Anti-FOXP2 (internal) Antibody

Peptide-affinity purified goat antibody

  • WB - Goat Anti-FOXP2 (internal) Antibody AF1437b
    AF1437b (0.3 µg/ml) staining of Human Brain (Cerebellum) lysate (35 µg protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.
  • IHC - Goat Anti-FOXP2 (internal) Antibody AF1437b
    AF1437b (2.5 µg/ml) staining of paraffin embedded Human Prostate. Steamed antigen retrieval with citrate buffer pH 6, AP-staining.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession O15409
Other Accession NP_683698, 93986, 114142 (mouse)
Reactivity Human, Rat
Predicted Mouse, Zebrafish, Pig, Dog, Cow, Cat
Host Goat
Clonality Polyclonal
Concentration 100ug/200ul
Isotype IgG
Calculated MW 79919 Da
Additional Information
Gene ID 93986
Other Names Forkhead box protein P2, CAG repeat protein 44, Trinucleotide repeat-containing gene 10 protein, FOXP2, CAGH44, TNRC10
Format 0.5 mg IgG/ml in Tris saline (20mM Tris pH7.3, 150mM NaCl), 0.02% sodium azide, with 0.5% bovine serum albumin
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsGoat Anti-FOXP2 (internal) Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name FOXP2
Synonyms CAGH44, TNRC10
Function Transcriptional repressor that may play a role in the specification and differentiation of lung epithelium. May also play a role in developing neural, gastrointestinal and cardiovascular tissues. Can act with CTBP1 to synergistically repress transcription but CTPBP1 is not essential. Plays a role in synapse formation by regulating SRPX2 levels. Involved in neural mechanisms mediating the development of speech and language.
Cellular Location Nucleus.
Tissue Location Isoform 1 and isoform 6 are expressed in adult and fetal brain, caudate nucleus and lung
Research Areas
Citations (0)

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This gene encodes a member of the forkhead/winged-helix (FOX) family of transcription factors. It is expressed in fetal and adult brain as well as in several other organs such as the lung and gut. The protein product contains a FOX DNA-binding domain and a large polyglutamine tract and is an evolutionarily conserved transcription factor, which may bind directly to approximately 300 to 400 gene promoters in the human genome to regulate the expression of a variety of genes. This gene is required for proper development of speech and language regions of the brain during embryogenesis, and may be involved in a variety of biological pathways and cascades that may ultimately influence language development. Mutations in this gene cause speech-language disorder 1 (SPCH1), also known as autosomal dominant speech and language disorder with orofacial dyspraxia. Multiple alternative transcripts encoding different isoforms have been identified in this gene.


FOXP2 gene and language impairment in schizophrenia: association and epigenetic studies. Tolosa A, et al. BMC Med Genet, 2010 Jul 22. PMID 20649982.
Maternal genes and facial clefts in offspring: a comprehensive search for genetic associations in two population-based cleft studies from Scandinavia. Jugessur A, et al. PLoS One, 2010 Jul 9. PMID 20634891.
Variation at the NFATC2 Locus Increases the Risk of Thiazolinedinedione-Induced Edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) Study. Bailey SD, et al. Diabetes Care, 2010 Jul 13. PMID 20628086.
New genetic associations detected in a host response study to hepatitis B vaccine. Davila S, et al. Genes Immun, 2010 Apr. PMID 20237496.
Foxp1/2/4-NuRD interactions regulate gene expression and epithelial injury response in the lung via regulation of interleukin-6. Chokas AL, et al. J Biol Chem, 2010 Apr 23. PMID 20185820.

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$ 325.00
Cat# AF1437b
(40 western blots)
Availability: 7-10 days
Bulk Size
Seasonal Special on Bulk Order
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