Goat Anti-FRA1 / FOSL1 Antibody
Peptide-affinity purified goat antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| WB, E |
---|---|
Primary Accession | P15407 |
Other Accession | NP_005429, 8061, 14283 (mouse), 25445 (rat) |
Reactivity | Human |
Predicted | Mouse, Rat, Pig, Dog, Cow |
Host | Goat |
Clonality | Polyclonal |
Concentration | 100ug/200ul |
Isotype | IgG |
Calculated MW | 29413 Da |
Gene ID | 8061 |
---|---|
Other Names | Fos-related antigen 1, FRA-1, FOSL1, FRA1 |
Format | 0.5 mg IgG/ml in Tris saline (20mM Tris pH7.3, 150mM NaCl), 0.02% sodium azide, with 0.5% bovine serum albumin |
Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
Precautions | Goat Anti-FRA1 / FOSL1 Antibody is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | FOSL1 |
---|---|
Synonyms | FRA1 |
Cellular Location | Nucleus {ECO:0000250|UniProtKB:P51145}. |
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Provided below are standard protocols that you may find useful for product applications.
Background
The Fos gene family consists of 4 members: FOS, FOSB, FOSL1, and FOSL2. These genes encode leucine zipper proteins that can dimerize with proteins of the JUN family, thereby forming the transcription factor complex AP-1. As such, the FOS proteins have been implicated as regulators of cell proliferation, differentiation, and transformation.
References
AP-1 (Fra-1/c-Jun)-mediated induction of expression of matrix metalloproteinase-2 is required for 15S-hydroxyeicosatetraenoic acid-induced angiogenesis. Singh NK, et al. J Biol Chem, 2010 May 28. PMID 20353950.
[Expression of the FOSL1 gene in psoriasis and atherosclerosis] Sobolev VV, et al. Genetika, 2010 Jan. PMID 20198886.
Human papillomavirus type 8 E2 protein unravels JunB/Fra-1 as an activator of the beta4-integrin gene in human keratinocytes. Oldak M, et al. J Virol, 2010 Feb. PMID 19923172.
Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip. Talmud PJ, et al. Am J Hum Genet, 2009 Nov. PMID 19913121.
Genetical genomic determinants of alcohol consumption in rats and humans. Tabakoff B, et al. BMC Biol, 2009 Oct 27. PMID 19874574.
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