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Goat Anti-FRAT2 / GSK-3 Antibody

Peptide-affinity purified goat antibody

  • WB - Goat Anti-FRAT2 / GSK-3 Antibody AF1442a
    AF1442a staining (2 µg/ml) of Human Heart lysate (RIPA buffer, 30 µg total protein per lane). Primary incubated for 1 hour. Detected by western blot using chemiluminescence.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession O75474
Other Accession NP_036215, 23401
Reactivity Human
Host Goat
Clonality Polyclonal
Concentration 100ug/200ul
Isotype IgG
Calculated MW 24051 Da
Additional Information
Gene ID 23401
Other Names GSK-3-binding protein FRAT2, Frequently rearranged in advanced T-cell lymphomas 2, FRAT-2, FRAT2
Format 0.5 mg IgG/ml in Tris saline (20mM Tris pH7.3, 150mM NaCl), 0.02% sodium azide, with 0.5% bovine serum albumin
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsGoat Anti-FRAT2 / GSK-3 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name FRAT2
Function Positively regulates the Wnt signaling pathway by stabilizing beta-catenin through the association with GSK-3.
Research Areas
Citations (0)

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The protein encoded by this intronless gene belongs to the GSK-3-binding protein family. Studies show that this protein plays a role as a positive regulator of the WNT signaling pathway. It may be upregulated in tumor progression.


Association between polymorphisms in Wnt signaling pathway genes and bone mineral density in postmenopausal Korean women. Lee DY, et al. Menopause, 2010 Sep-Oct. PMID 20613673.
Activation of glycogen synthase kinase-3 inhibits protein phosphatase-2A and the underlying mechanisms. Liu GP, et al. Neurobiol Aging, 2008 Sep. PMID 17433504.
FRAT-2 preferentially increases glycogen synthase kinase 3 beta-mediated phosphorylation of primed sites, which results in enhanced tau phosphorylation. Stoothoff WH, et al. J Biol Chem, 2005 Jan 7. PMID 15522877.
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Gerhard DS, et al. Genome Res, 2004 Oct. PMID 15489334.
The DNA sequence and comparative analysis of human chromosome 10. Deloukas P, et al. Nature, 2004 May 27. PMID 15164054.

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$ 325.00
Cat# AF1442a
(40 western blots)
Availability: 7-10 days
Bulk Size
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