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Goat Anti-FTO (Mouse) Antibody

Peptide-affinity purified goat antibody

  • WB - Goat Anti-FTO (Mouse) Antibody AF1448a
    AF1448a (0.03 µg/ml) staining of Human Pancreas lysate (35 µg protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q9C0B1
Other Accession NP_036066, 79068, 26383 (mouse), 291905 (rat)
Reactivity Human
Predicted Mouse, Rat, Pig, Dog
Host Goat
Clonality Polyclonal
Concentration 100ug/200ul
Isotype IgG
Calculated MW 58282 Da
Additional Information
Gene ID 79068
Other Names Alpha-ketoglutarate-dependent dioxygenase FTO, 1.14.11.-, Fat mass and obesity-associated protein, FTO, KIAA1752
Format 0.5 mg IgG/ml in Tris saline (20mM Tris pH7.3, 150mM NaCl), 0.02% sodium azide, with 0.5% bovine serum albumin
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsGoat Anti-FTO (Mouse) Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name FTO
Synonyms KIAA1752
Function Dioxygenase that repairs alkylated DNA and RNA by oxidative demethylation. Has highest activity towards single- stranded RNA containing 3-methyluracil, followed by single- stranded DNA containing 3-methylthymine. Has low demethylase activity towards single-stranded DNA containing 1-methyladenine or 3-methylcytosine. Specifically demethylates N(6)-methyladenosine (m6A) RNA, the most prevalent internal modification of messenger RNA (mRNA) in higher eukaryotes. Has no activity towards 1- methylguanine. Has no detectable activity towards double-stranded DNA. Requires molecular oxygen, alpha-ketoglutarate and iron. Contributes to the regulation of the global metabolic rate, energy expenditure and energy homeostasis. Contributes to the regulation of body size and body fat accumulation.
Cellular Location Nucleus. Nucleus speckle
Tissue Location Ubiquitously expressed, with relatively high expression in adrenal glands and brain; especially in hypothalamus and pituitary.
Research Areas
Citations (0)

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FTO effect on energy demand versus food intake. Speakman JR. Nature, 2010 Apr 1. PMID 20360686.
Hypothalamic FTO is associated with the regulation of energy intake not feeding reward. Olszewski PK, et al. BMC Neurosci, 2009 Oct 27. PMID 19860904.
A mouse model for the metabolic effects of the human fat mass and obesity associated FTO gene. Church C, et al. PLoS Genet, 2009 Aug. PMID 19680540.
Loss-of-function mutation in the dioxygenase-encoding FTO gene causes severe growth retardation and multiple malformations. Boissel S, et al. Am J Hum Genet, 2009 Jul. PMID 19559399.
Inactivation of the Fto gene protects from obesity. Fischer J, et al. Nature, 2009 Apr 16. PMID 19234441.

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$ 325.00
Cat# AF1448a
(40 western blots)
Availability: 7-10 days
Bulk Size
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