|Application ||WB, E|
|Other Accession||NP_001013457, 8087, 14359 (mouse), 361927 (rat)|
|Predicted||Human, Rat, Dog|
|Calculated MW||69721 Da|
|Other Names||Fragile X mental retardation syndrome-related protein 1, hFXR1p, FXR1|
|Format||0.5 mg IgG/ml in Tris saline (20mM Tris pH7.3, 150mM NaCl), 0.02% sodium azide, with 0.5% bovine serum albumin|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||Goat Anti-FXR1 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||RNA-binding protein required for embryonic and postnatal development of muscle tissue. May regulate intracellular transport and local translation of certain mRNAs (By similarity).|
|Tissue Location||Expressed in all tissues examined including heart, brain, kidney and testis.|
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Provided below are standard protocols that you may find useful for product applications.
The protein encoded by this gene is an RNA binding protein that interacts with the functionally-similar proteins FMR1 and FXR2. These proteins shuttle between the nucleus and cytoplasm and associate with polyribosomes, predominantly with the 60S ribosomal subunit. Three transcript variants encoding different isoforms have been found for this gene.
Common polygenic variation contributes to risk of schizophrenia and bipolar disorder. International Schizophrenia Consortium, et al. Nature, 2009 Aug 6. PMID 19571811.
Discrimination of common and unique RNA-binding activities among Fragile X mental retardation protein paralogs. Darnell JC, et al. Hum Mol Genet, 2009 Sep 1. PMID 19487368.
Alteration of expression of muscle specific isoforms of the fragile X related protein 1 (FXR1P) in facioscapulohumeral muscular dystrophy patients. Davidovic L, et al. J Med Genet, 2008 Oct. PMID 18628314.
Toward a confocal subcellular atlas of the human proteome. Barbe L, et al. Mol Cell Proteomics, 2008 Mar. PMID 18029348.
AU-rich-element-mediated upregulation of translation by FXR1 and Argonaute 2. Vasudevan S, et al. Cell, 2007 Mar 23. PMID 17382880.
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