|Application ||WB, IHC, E|
|Other Accession||NP_002090, 2993|
|Calculated MW||16331 Da|
|Other Names||Glycophorin-A, MN sialoglycoprotein, PAS-2, Sialoglycoprotein alpha, CD235a, GYPA, GPA|
|Format||0.5 mg IgG/ml in Tris saline (20mM Tris pH7.3, 150mM NaCl), 0.02% sodium azide, with 0.5% bovine serum albumin|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||Goat Anti-Glycophorin A Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Glycophorin A is the major intrinsic membrane protein of the erythrocyte. The N-terminal glycosylated segment, which lies outside the erythrocyte membrane, has MN blood group receptors. Appears to be important for the function of SLC4A1 and is required for high activity of SLC4A1. May be involved in translocation of SLC4A1 to the plasma membrane. Is a receptor for influenza virus. Is a receptor for Plasmodium falciparum erythrocyte-binding antigen 175 (EBA-175); binding of EBA-175 is dependent on sialic acid residues of the O-linked glycans. Appears to be a receptor for Hepatitis A virus (HAV).|
|Cellular Location||Cell membrane; Single-pass type I membrane protein Note=Appears to be colocalized with SLC4A1|
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Provided below are standard protocols that you may find useful for product applications.
Glycophorins A (GYPA) and B (GYPB) are major sialoglycoproteins of the human erythrocyte membrane which bear the antigenic determinants for the MN and Ss blood groups. In addition to the M or N and S or s antigens that commonly occur in all populations, about 40 related variant phenotypes have been identified. These variants include all the variants of the Miltenberger complex and several isoforms of Sta, as well as Dantu, Sat, He, Mg, and deletion variants Ena, S-s-U- and Mk. Most of the variants are the result of gene recombinations between GYPA and GYPB.
Robust, high-throughput solution for blood group genotyping. Le Goff GC, et al. Anal Chem, 2010 Jul 15. PMID 20560530.
ABH blood group antigens in N-glycan of human glycophorin A. Fredriksson SA, et al. Arch Biochem Biophys, 2010 Jun 15. PMID 20434428.
A new isoform of Sta gene found in a family with NOR polyagglutination. Suchanowska A, et al. Transfusion, 2010 Feb. PMID 20233359.
Variants in FAM13A are associated with chronic obstructive pulmonary disease. Cho MH, et al. Nat Genet, 2010 Mar. PMID 20173748.
Unfolding a transmembrane helix dimer: A FRET study in mixed micelles. Anbazhagan V, et al. Arch Biochem Biophys, 2010 Mar 15. PMID 20074546.
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