|Application ||WB, E|
|Other Accession||NP_115943, 27198|
|Calculated MW||39295 Da|
|Other Names||Hydroxycarboxylic acid receptor 1, G-protein coupled receptor 104, G-protein coupled receptor 81, HCAR1, GPR104, GPR81, HCA1|
|Format||0.5 mg IgG/ml in Tris saline (20mM Tris pH7.3, 150mM NaCl), 0.02% sodium azide, with 0.5% bovine serum albumin|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||Goat Anti-GPR81 / FKSG80 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Synonyms||GPR104, GPR81, HCA1|
|Function||Acts as a receptor for L-lactate and mediates its anti- lipolytic effect through a G(i)-protein-mediated pathway.|
|Cellular Location||Cell membrane; Multi-pass membrane protein.|
|Tissue Location||Expressed abundantly in brown and white fat. It also detectable at lower levels in liver, kidney, skeletal muscle, brain and pituitary. Not detected in frontal, temporal and occipital lobes of the cortex, basal forebrain, caudate nucleus, nucleus accumbens and hippocampus.|
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Provided below are standard protocols that you may find useful for product applications.
G protein-coupled receptors (GPCRs, or GPRs), such as GPR81, contain 7 transmembrane domains and transduce extracellular signals through heterotrimeric G proteins.
Variation at the NFATC2 Locus Increases the Risk of Thiazolinedinedione-Induced Edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) Study. Bailey SD, et al. Diabetes Care, 2010 Jul 13. PMID 20628086.
Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip. Talmud PJ, et al. Am J Hum Genet, 2009 Nov. PMID 19913121.
Peroxisome proliferator-activated receptor gamma regulates expression of the anti-lipolytic G-protein-coupled receptor 81 (GPR81/Gpr81). Jeninga EH, et al. J Biol Chem, 2009 Sep 25. PMID 19633298.
Lactate inhibits lipolysis in fat cells through activation of an orphan G-protein-coupled receptor, GPR81. Liu C, et al. J Biol Chem, 2009 Jan 30. PMID 19047060.
Role of GPR81 in lactate-mediated reduction of adipose lipolysis. Cai TQ, et al. Biochem Biophys Res Commun, 2008 Dec 19. PMID 18952058.
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