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Goat Anti-Granulin / GRN Antibody

Peptide-affinity purified goat antibody

  • WB - Goat Anti-Granulin / GRN Antibody AF1504a
    AF1504a (1 µg/ml) staining of HeLa lysate (35 µg protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession P28799
Other Accession NP_002078, 2896
Reactivity Human
Host Goat
Clonality Polyclonal
Concentration 100ug/200ul
Isotype IgG
Calculated MW 63544 Da
Additional Information
Gene ID 2896
Other Names Granulins, Proepithelin, PEPI, Acrogranin, Glycoprotein of 88 Kda, GP88, Glycoprotein 88, Progranulin, Paragranulin, Granulin-1, Granulin G, Granulin-2, Granulin F, Granulin-3, Granulin B, Granulin-4, Granulin A, Granulin-5, Granulin C, Granulin-6, Granulin D, Granulin-7, Granulin E, GRN
Format 0.5 mg IgG/ml in Tris saline (20mM Tris pH7.3, 150mM NaCl), 0.02% sodium azide, with 0.5% bovine serum albumin
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsGoat Anti-Granulin / GRN Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name GRN
Function Granulins have possible cytokine-like activity. They may play a role in inflammation, wound repair, and tissue remodeling.
Cellular Location Secreted.
Tissue Location In myelogenous leukemic cell lines of promonocytic, promyelocytic, and proerythroid lineage, in fibroblasts, and very strongly in epithelial cell lines. Present in inflammatory cells and bone marrow. Highest levels in kidney
Research Areas
Citations (0)

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Granulins are a family of secreted, glycosylated peptides that are cleaved from a single precursor protein with 7.5 repeats of a highly conserved 12-cysteine granulin/epithelin motif. The 88 kDa precursor protein, progranulin, is also called proepithelin and PC cell-derived growth factor. Cleavage of the signal peptide produces mature granulin which can be further cleaved into a variety of active, 6 kDa peptides. These smaller cleavage products are named granulin A, granulin B, granulin C, etc. Epithelins 1 and 2 are synonymous with granulins A and B, respectively. Both the peptides and intact granulin protein regulate cell growth. However, different members of the granulin protein family may act as inhibitors, stimulators, or have dual actions on cell growth. Granulin family members are important in normal development, wound healing, and tumorigenesis.


Prion Protein Codon 129 Polymorphism Modifies Age at Onset of Frontotemporal Dementia With the C.709-1G>A Progranulin Mutation. Moreno F, et al. Alzheimer Dis Assoc Disord, 2010 Aug 12. PMID 20711061.
Variation at the NFATC2 Locus Increases the Risk of Thiazolinedinedione-Induced Edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) Study. Bailey SD, et al. Diabetes Care, 2010 Jul 13. PMID 20628086.
MicroRNA-29b regulates the expression level of human progranulin, a secreted glycoprotein implicated in frontotemporal dementia. Jiao J, et al. PLoS One, 2010 May 10. PMID 20479936.
Progranulin gene variability increases the risk for primary progressive multiple sclerosis in males. Fenoglio C, et al. Genes Immun, 2010 Sep. PMID 20463744.
Role of progranulin as a biomarker for Alzheimer's disease. Sleegers K, et al. Biomark Med, 2010 Feb. PMID 20387302.

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$ 325.00
Cat# AF1504a
(40 western blots)
Availability: 7-10 days
Bulk Size
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