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Goat Anti-GRAP Antibody

Peptide-affinity purified goat antibody

     
  • WB - Goat Anti-GRAP Antibody AF1505a
    AF1505a (0.3 µg/ml) staining of human thymus lysate (35 µg protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.
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  • SPECIFICATION
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, E
Primary Accession Q13588
Other Accession NP_006604, 10750, 71520 (mouse)
Reactivity Human
Predicted Mouse, Rat, Cow
Host Goat
Clonality Polyclonal
Concentration 100ug/200ul
Isotype IgG
Calculated MW 25337 Da
Additional Information
Gene ID 10750
Other Names GRB2-related adapter protein, GRAP
Format 0.5 mg IgG/ml in Tris saline (20mM Tris pH7.3, 150mM NaCl), 0.02% sodium azide, with 0.5% bovine serum albumin
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsGoat Anti-GRAP Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name GRAP (HGNC:4562)
Function Couples signals from receptor and cytoplasmic tyrosine kinases to the Ras signaling pathway. Plays a role in the inner ear and in hearing (PubMed:30610177).
Cellular Location Membrane {ECO:0000250|UniProtKB:Q08012}; Peripheral membrane protein {ECO:0000250|UniProtKB:Q08012}. Synapse {ECO:0000250|UniProtKB:Q08012}. Note=Localizes at the presynaptic terminal. {ECO:0000250|UniProtKB:Q08012}
Research Areas
Citations (0)
citation

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Background

This gene encodes a member of the GRB2/Sem5/Drk family. This member functions as a cytoplasmic signaling protein which contains an SH2 domain flanked by two SH3 domains. The SH2 domain interacts with ligand-activated receptors for stem cell factor and erythropoietin, and facilitates the formation of a stable complex with the BCR-ABL oncoprotein. This protein also associates with the Ras guanine nucleotide exchange factor SOS1 (son of sevenless homolog 1) through its N-terminal SH3 domain.

References

Quantitative mass spectrometry of diabetic kidney tubules identifies GRAP as a novel regulator of TGF-beta signaling. Cummins TD, et al. Biochim Biophys Acta, 2010 Apr. PMID 19836472.
CD28 and Grb-2, relative to Gads or Grap, preferentially co-operate with Vav1 in the activation of NFAT/AP-1 transcription. Schneider H, et al. Biochem Biophys Res Commun, 2008 May 2. PMID 18295596.
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Gerhard DS, et al. Genome Res, 2004 Oct. PMID 15489334.
Detection of Grb-2-related adaptor protein gene (GRAP) and peptide molecule in salivary glands of MRL/lpr mice and patients with Sj枚gren's syndrome. Shiraiwa H, et al. J Int Med Res, 2004 May-Jun. PMID 15174222.
GC-GAP, a Rho family GTPase-activating protein that interacts with signaling adapters Gab1 and Gab2. Zhao C, et al. J Biol Chem, 2003 Sep 5. PMID 12819203.

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$ 341.00
Cat# AF1505a
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Availability: 7-10 days
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