|Application ||WB, E|
|Other Accession||NP_006604, 10750, 71520 (mouse)|
|Predicted||Mouse, Rat, Cow|
|Calculated MW||25337 Da|
|Other Names||GRB2-related adapter protein, GRAP|
|Format||0.5 mg IgG/ml in Tris saline (20mM Tris pH7.3, 150mM NaCl), 0.02% sodium azide, with 0.5% bovine serum albumin|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||Goat Anti-GRAP Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Couples signals from receptor and cytoplasmic tyrosine kinases to the Ras signaling pathway.|
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Provided below are standard protocols that you may find useful for product applications.
This gene encodes a member of the GRB2/Sem5/Drk family. This member functions as a cytoplasmic signaling protein which contains an SH2 domain flanked by two SH3 domains. The SH2 domain interacts with ligand-activated receptors for stem cell factor and erythropoietin, and facilitates the formation of a stable complex with the BCR-ABL oncoprotein. This protein also associates with the Ras guanine nucleotide exchange factor SOS1 (son of sevenless homolog 1) through its N-terminal SH3 domain.
Quantitative mass spectrometry of diabetic kidney tubules identifies GRAP as a novel regulator of TGF-beta signaling. Cummins TD, et al. Biochim Biophys Acta, 2010 Apr. PMID 19836472.
CD28 and Grb-2, relative to Gads or Grap, preferentially co-operate with Vav1 in the activation of NFAT/AP-1 transcription. Schneider H, et al. Biochem Biophys Res Commun, 2008 May 2. PMID 18295596.
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Gerhard DS, et al. Genome Res, 2004 Oct. PMID 15489334.
Detection of Grb-2-related adaptor protein gene (GRAP) and peptide molecule in salivary glands of MRL/lpr mice and patients with Sj枚gren's syndrome. Shiraiwa H, et al. J Int Med Res, 2004 May-Jun. PMID 15174222.
GC-GAP, a Rho family GTPase-activating protein that interacts with signaling adapters Gab1 and Gab2. Zhao C, et al. J Biol Chem, 2003 Sep 5. PMID 12819203.
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