|Application ||WB, E|
|Other Accession||NP_006398, 10550|
|Calculated MW||21615 Da|
|Other Names||PRA1 family protein 3, ADP-ribosylation factor-like protein 6-interacting protein 5, ARL-6-interacting protein 5, Aip-5, Cytoskeleton-related vitamin A-responsive protein, Dermal papilla-derived protein 11, GTRAP3-18, Glutamate transporter EAAC1-interacting protein, JM5, Prenylated Rab acceptor protein 2, Protein JWa, Putative MAPK-activating protein PM27, ARL6IP5, DERP11, JWA, PRA2, PRAF3|
|Format||0.5 mg IgG/ml in Tris saline (20mM Tris pH7.3, 150mM NaCl), 0.02% sodium azide, with 0.5% bovine serum albumin|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||Goat Anti-GTRAP3-18 / JWA Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Synonyms||DERP11, JWA, PRA2, PRAF3|
|Function||Regulates intracellular concentrations of taurine and glutamate. Negatively modulates SLC1A1/EAAC1 glutamate transport activity by decreasing its affinity for glutamate. May be involved in membrane traffic (By similarity).|
|Cellular Location||Endoplasmic reticulum membrane; Multi-pass membrane protein Cytoplasm. Note=Also exists as a soluble form in the cytoplasm. Associated with microtubules (By similarity)|
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Provided below are standard protocols that you may find useful for product applications.
Expression of this gene is affected by vitamin A. The encoded protein of this gene may be associated with the cytoskeleton. A similar protein in rats may play a role in the regulation of cell differentiation. The rat protein binds and inhibits the cell membrane glutamate transporter EAAC1. The expression of the rat gene is upregulated by retinoic acid, which results in a specific reduction in EAAC1-mediated glutamate transport.
Genome-wide association study of alcohol dependence implicates a region on chromosome 11. Edenberg HJ, et al. Alcohol Clin Exp Res, 2010 May. PMID 20201924.
Modulation of the neural glutamate transporter EAAC1 by the addicsin-interacting protein ARL6IP1. Akiduki S, et al. J Biol Chem, 2008 Nov 14. PMID 18684713.
The endoplasmic reticulum exit of glutamate transporter is regulated by the inducible mammalian Yip6b/GTRAP3-18 protein. Ruggiero AM, et al. J Biol Chem, 2008 Mar 7. PMID 18167356.
Toward a confocal subcellular atlas of the human proteome. Barbe L, et al. Mol Cell Proteomics, 2008 Mar. PMID 18029348.
Regulation of glutathione synthesis via interaction between glutamate transport-associated protein 3-18 (GTRAP3-18) and excitatory amino acid carrier-1 (EAAC1) at plasma membrane. Watabe M, et al. Mol Pharmacol, 2007 Nov. PMID 17646425.
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