|Application ||WB, IHC, E|
|Other Accession||NP_057399, 51454, 70676 (mouse)|
|Predicted||Mouse, Rat, Dog|
|Calculated MW||34490 Da|
|Other Names||PTB domain-containing engulfment adapter protein 1, Cell death protein 6 homolog, PTB domain adapter protein CED-6, Protein GULP, GULP1, CED6, GULP|
|Format||0.5 mg IgG/ml in Tris saline (20mM Tris pH7.3, 150mM NaCl), 0.02% sodium azide, with 0.5% bovine serum albumin|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||Goat Anti-GULP1 / CED6 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||May function as an adapter protein. Required for efficient phagocytosis of apoptotic cells. Modulates cellular glycosphingolipid and cholesterol transport. May play a role in the internalization and endosomal trafficking of various LRP1 ligands, such as PSAP. Increases cellular levels of GTP-bound ARF6.|
|Cellular Location||Cytoplasm. Note=May associate with the cytoplasmic side of the plasma membrane and early endosomes|
|Tissue Location||Widely expressed. Detected in macrophages, pancreas, kidney, skeletal muscle, heart, colon, intestine, lung, placenta and ovary.|
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Provided below are standard protocols that you may find useful for product applications.
The prompt clearance of cells undergoing apoptosis is critical during embryonic development, normal tissue turnover, inflammation, and autoimmunity. CED6 is an evolutionarily conserved adaptor protein required for efficient engulfment of apoptotic cells by phagocytes.
Adaptor protein GULP is involved in stabilin-1-mediated phagocytosis. Park SY, et al. Biochem Biophys Res Commun, 2010 Jul 30. PMID 20599701.
New genetic associations detected in a host response study to hepatitis B vaccine. Davila S, et al. Genes Immun, 2010 Apr. PMID 20237496.
Apoptotic engulfment pathway and schizophrenia. Chen X, et al. PLoS One, 2009 Sep 1. PMID 19721717.
Signalling pathway involving GULP, MAPK and Rac1 for SR-BI-induced phagocytosis of apoptotic cells. Osada Y, et al. J Biochem, 2009 Mar. PMID 19122200.
Requirement of adaptor protein GULP during stabilin-2-mediated cell corpse engulfment. Park SY, et al. J Biol Chem, 2008 Apr 18. PMID 18230608.
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