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Goat Anti-H11 / HSP22 Antibody

Peptide-affinity purified goat antibody

  • WB - Goat Anti-H11 / HSP22 Antibody AF1517a
    AF1517a staining (1 µg/ml) of human muscle lysate (RIPA buffer, 30 µg total protein per lane). Primary incubated for 1 hour. Detected by western blot using chemiluminescence.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q9UJY1
Other Accession NP_055180, 26353
Reactivity Human
Host Goat
Clonality Polyclonal
Concentration 100ug/200ul
Isotype IgG
Calculated MW 21604 Da
Additional Information
Gene ID 26353
Other Names Heat shock protein beta-8, HspB8, Alpha-crystallin C chain, E2-induced gene 1 protein, Protein kinase H11, Small stress protein-like protein HSP22, HSPB8, CRYAC, E2IG1, HSP22
Format 0.5 mg IgG/ml in Tris saline (20mM Tris pH7.3, 150mM NaCl), 0.02% sodium azide, with 0.5% bovine serum albumin
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsGoat Anti-H11 / HSP22 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name HSPB8
Synonyms CRYAC, E2IG1, HSP22
Function Displays temperature-dependent chaperone activity.
Cellular Location Cytoplasm. Nucleus. Note=Translocates to nuclear foci during heat shock
Tissue Location Predominantly expressed in skeletal muscle and heart.
Research Areas
Citations (0)

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The protein encoded by this gene belongs to the superfamily of small heat-shock proteins containing a conservative alpha-crystallin domain at the C-terminal part of the molecule. The expression of this gene in induced by estrogen in estrogen receptor-positive breast cancer cells, and this protein also functions as a chaperone in association with Bag3, a stimulator of macroautophagy. Thus, this gene appears to be involved in regulation of cell proliferation, apoptosis, and carcinogenesis, and mutations in this gene have been associated with different neuromuscular diseases, including Charcot-Marie-Tooth disease.


New genetic associations detected in a host response study to hepatitis B vaccine. Davila S, et al. Genes Immun, 2010 Apr. PMID 20237496.
Identification of the key structural motifs involved in HspB8/HspB6-Bag3 interaction. Fuchs M, et al. Biochem J, 2009 Dec 14. PMID 19845507.
Thermally induced structural changes of intrinsically disordered small heat shock protein Hsp22. Kazakov AS, et al. Biophys Chem, 2009 Dec. PMID 19783089.
Genetic susceptibility to distinct bladder cancer subphenotypes. Guey LT, et al. Eur Urol, 2010 Feb. PMID 19692168.
PTEN identified as important risk factor of chronic obstructive pulmonary disease. Hosgood HD 3rd, et al. Respir Med, 2009 Dec. PMID 19625176.

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$ 325.00
Cat# AF1517a
(40 western blots)
Availability: 7-10 days
Bulk Size
Seasonal Special on Bulk Order
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