|Application ||WB, E|
|Other Accession||NP_060480, 55081, 73916 (mouse), 303968 (rat)|
|Calculated MW||49108 Da|
|Other Names||Intraflagellar transport protein 57 homolog, Dermal papilla-derived protein 8, Estrogen-related receptor beta-like protein 1, HIP1-interacting protein, MHS4R2, IFT57, DERP8, ESRRBL1, HIPPI|
|Format||0.5 mg IgG/ml in Tris saline (20mM Tris pH7.3, 150mM NaCl), 0.02% sodium azide, with 0.5% bovine serum albumin|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||Goat Anti-HIPPI Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Synonyms||DERP8, ESRRBL1, HIPPI|
|Function||Required for the formation of cilia. Plays an indirect role in sonic hedgehog signaling, cilia being required for all activity of the hedgehog pathway (By similarity). Has pro- apoptotic function via its interaction with HIP1, leading to recruit caspase-8 (CASP8) and trigger apoptosis. Has the ability to bind DNA sequence motif 5'-AAAGACATG-3' present in the promoter of caspase genes such as CASP1, CASP8 and CASP10, suggesting that it may act as a transcription regulator; however the relevance of such function remains unclear.|
|Cellular Location||Cytoplasm, cytoskeleton, cilium basal body. Note=Concentrates within the inner segment of cilia.|
|Tissue Location||Present in many tissues such as brain, thymus, lymph node, lung, liver, skin and kidney (at protein level)|
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Provided below are standard protocols that you may find useful for product applications.
BLOC1S2 interacts with the HIPPI protein and sensitizes NCH89 glioblastoma cells to apoptosis. Gdynia G, et al. Apoptosis, 2008 Mar. PMID 18188704.
Interaction of HIPPI with putative promoter sequence of caspase-1 in vitro and in vivo. Majumder P, et al. Biochem Biophys Res Commun, 2007 Feb 2. PMID 17173859.
Cloning, expression, purification, crystallization and preliminary crystallographic analysis of pseudo death-effector domain of HIPPI, a molecular partner of Huntingtin-interacting protein HIP-1. Banerjee M, et al. Acta Crystallogr Sect F Struct Biol Cryst Commun, 2006 Dec 1. PMID 17142908.
Induction of apoptosis in cells expressing exogenous Hippi, a molecular partner of huntingtin-interacting protein Hip1. Majumder P, et al. Neurobiol Dis, 2006 May. PMID 16364650.
Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. Kimura K, et al. Genome Res, 2006 Jan. PMID 16344560.
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