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Goat Anti-HPK1 / MAP4K1 Antibody

Peptide-affinity purified goat antibody

  • WB - Goat Anti-HPK1 / MAP4K1 Antibody AF1538a
    AF1538a staining (0.5 µg/ml) of Jurkat lysate (RIPA buffer, 35 µg total protein per lane). Primary incubated for 1 hour. Detected by western blot using chemiluminescence.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q92918
Other Accession NP_009112, 11184
Reactivity Human
Predicted Mouse, Rat, Pig, Dog, Cow
Host Goat
Clonality Polyclonal
Concentration 100ug/200ul
Isotype IgG
Calculated MW 91296 Da
Additional Information
Gene ID 11184
Other Names Mitogen-activated protein kinase kinase kinase kinase 1,, Hematopoietic progenitor kinase, MAPK/ERK kinase kinase kinase 1, MEK kinase kinase 1, MEKKK 1, MAP4K1, HPK1
Format 0.5 mg IgG/ml in Tris saline (20mM Tris pH7.3, 150mM NaCl), 0.02% sodium azide, with 0.5% bovine serum albumin
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsGoat Anti-HPK1 / MAP4K1 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name MAP4K1
Synonyms HPK1
Function Serine/threonine-protein kinase, which may play a role in the response to environmental stress. Appears to act upstream of the JUN N-terminal pathway. May play a role in hematopoietic lineage decisions and growth regulation. Able to autophosphorylate.
Tissue Location Expressed primarily in hematopoietic organs, including bone marrow, spleen and thymus. Also expressed at very low levels in lung, kidney, mammary glands and small intestine
Research Areas
Citations (0)

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Phosphorylation of CARMA1 by HPK1 is critical for NF-kappaB activation in T cells. Brenner D, et al. Proc Natl Acad Sci U S A, 2009 Aug 25. PMID 19706536.
Proteasome-mediated degradation and functions of hematopoietic progenitor kinase 1 in pancreatic cancer. Wang H, et al. Cancer Res, 2009 Feb 1. PMID 19141650.
Prostaglandin E2 activates HPK1 kinase activity via a PKA-dependent pathway. Sawasdikosol S, et al. J Biol Chem, 2007 Nov 30. PMID 17895239.
Caspase-cleaved HPK1 induces CD95L-independent activation-induced cell death in T and B lymphocytes. Brenner D, et al. Blood, 2007 Dec 1. PMID 17712048.
Systematic identification of SH3 domain-mediated human protein-protein interactions by peptide array target screening. Wu C, et al. Proteomics, 2007 Jun. PMID 17474147.

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$ 325.00
Cat# AF1538a
(40 western blots)
Availability: 7-10 days
Bulk Size
Seasonal Special on Bulk Order
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