- CITATIONS: 1
|Application ||WB, E|
|Other Accession||NP_009112, 11184|
|Predicted||Mouse, Rat, Pig, Dog, Cow|
|Calculated MW||91296 Da|
|Other Names||Mitogen-activated protein kinase kinase kinase kinase 1, 188.8.131.52, Hematopoietic progenitor kinase, MAPK/ERK kinase kinase kinase 1, MEK kinase kinase 1, MEKKK 1, MAP4K1, HPK1|
|Format||0.5 mg IgG/ml in Tris saline (20mM Tris pH7.3, 150mM NaCl), 0.02% sodium azide, with 0.5% bovine serum albumin|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||Goat Anti-HPK1 / MAP4K1 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Serine/threonine-protein kinase, which may play a role in the response to environmental stress. Appears to act upstream of the JUN N-terminal pathway. May play a role in hematopoietic lineage decisions and growth regulation. Able to autophosphorylate.|
|Tissue Location||Expressed primarily in hematopoietic organs, including bone marrow, spleen and thymus. Also expressed at very low levels in lung, kidney, mammary glands and small intestine|
Provided below are standard protocols that you may find useful for product applications.
Phosphorylation of CARMA1 by HPK1 is critical for NF-kappaB activation in T cells. Brenner D, et al. Proc Natl Acad Sci U S A, 2009 Aug 25. PMID 19706536.
Proteasome-mediated degradation and functions of hematopoietic progenitor kinase 1 in pancreatic cancer. Wang H, et al. Cancer Res, 2009 Feb 1. PMID 19141650.
Prostaglandin E2 activates HPK1 kinase activity via a PKA-dependent pathway. Sawasdikosol S, et al. J Biol Chem, 2007 Nov 30. PMID 17895239.
Caspase-cleaved HPK1 induces CD95L-independent activation-induced cell death in T and B lymphocytes. Brenner D, et al. Blood, 2007 Dec 1. PMID 17712048.
Systematic identification of SH3 domain-mediated human protein-protein interactions by peptide array target screening. Wu C, et al. Proteomics, 2007 Jun. PMID 17474147.
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