|Application ||WB, E|
|Other Accession||NP_861420, 3290|
|Calculated MW||32401 Da|
|Other Names||Corticosteroid 11-beta-dehydrogenase isozyme 1, 18.104.22.168, 11-beta-hydroxysteroid dehydrogenase 1, 11-DH, 11-beta-HSD1, HSD11B1, HSD11, HSD11L|
|Format||0.5 mg IgG/ml in Tris saline (20mM Tris pH7.3, 150mM NaCl), 0.02% sodium azide, with 0.5% bovine serum albumin|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||Goat Anti-HSD11B1 / HDL Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Synonyms||HSD11, HSD11L, SDR26C1|
|Function||Catalyzes reversibly the conversion of cortisol to the inactive metabolite cortisone. Catalyzes reversibly the conversion of 7-ketocholesterol to 7-beta-hydroxycholesterol. In intact cells, the reaction runs only in one direction, from 7- ketocholesterol to 7-beta-hydroxycholesterol (By similarity).|
|Cellular Location||Endoplasmic reticulum membrane; Single-pass type II membrane protein|
|Tissue Location||Widely expressed. Highest expression in liver.|
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Provided below are standard protocols that you may find useful for product applications.
The protein encoded by this gene is a microsomal enzyme that catalyzes the conversion of the stress hormone cortisol to the inactive metabolite cortisone. In addition, the encoded protein can catalyze the reverse reaction, the conversion of cortisone to cortisol. Too much cortisol can lead to central obesity, and a particular variation in this gene has been associated with obesity and insulin resistance in children. Two transcript variants encoding the same protein have been found for this gene.
SRD5A2 is associated with increased cortisol metabolism in schizophrenia spectrum disorders. Steen NE, et al. Prog Neuropsychopharmacol Biol Psychiatry, 2010 Aug 25. PMID 20800085.
Variation at the NFATC2 Locus Increases the Risk of Thiazolinedinedione-Induced Edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) Study. Bailey SD, et al. Diabetes Care, 2010 Jul 13. PMID 20628086.
Genetic variants in the renin-angiotensin-aldosterone system and salt sensitivity of blood pressure. Gu D, et al. J Hypertens, 2010 Jun. PMID 20486282.
Identification of type 2 diabetes-associated combination of SNPs using support vector machine. Ban HJ, et al. BMC Genet, 2010 Apr 23. PMID 20416077.
Genetic variation in the estrogen metabolic pathway and mammographic density as an intermediate phenotype of breast cancer. Li J, et al. Breast Cancer Res, 2010. PMID 20214802.
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