|Application ||WB, E|
|Other Accession||NP_002837, 5798, 19275 (mouse), 116660 (rat)|
|Calculated MW||105848 Da|
|Other Names||Receptor-type tyrosine-protein phosphatase-like N, R-PTP-N, Islet cell antigen 512, ICA 512, Islet cell autoantigen 3, PTP IA-2, PTPRN, ICA3, ICA512|
|Format||0.5 mg IgG/ml in Tris saline (20mM Tris pH7.3, 150mM NaCl), 0.02% sodium azide, with 0.5% bovine serum albumin|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||Goat Anti-IA2 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Implicated in neuroendocrine secretory processes. May be involved in processes specific for neurosecretory granules, such as their biogenesis, trafficking or regulated exocytosis or may have a general role in neuroendocrine functions. Seems to lack intrinsic enzyme activity. May play a role in the regulation of secretory granules via its interaction with SNTB2.|
|Cellular Location||Membrane; Single-pass type I membrane protein. Note=Neuroendocrine secretory granules|
|Tissue Location||Expression is restricted to neuroendocrine cells. Found in pancreas, brain and pituitary|
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Provided below are standard protocols that you may find useful for product applications.
The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP possesses an extracellular region, a single transmembrane region, and a single catalytic domain, and thus represents a receptor-type PTP. This PTP was found to be an autoantigen that is reactive with insulin-dependent diabetes mellitus (IDDM) patient sera, and thus may be a potential target of autoimmunity in diabetes mellitus.
Evidence for molecular mimicry between human T cell epitopes in rotavirus and pancreatic islet autoantigens. Honeyman MC, et al. J Immunol, 2010 Feb 15. PMID 20083660.
Triple chimeric islet autoantigen IA2-ZnT8WR to facilitate islet autoantibody determination. Yu L, et al. J Immunol Methods, 2010 Feb 28. PMID 20035758.
Autoantibodies and associated T-cell responses to determinants within the 831-860 region of the autoantigen IA-2 in Type 1 diabetes. Weenink SM, et al. J Autoimmun, 2009 Sep. PMID 19447008.
A new luminescence assay for autoantibodies to mammalian cell-prepared insulinoma-associated protein 2. Burbelo PD, et al. Diabetes Care, 2008 Sep. PMID 18535195.
Autoantibodies to islet antigen-2 are associated with HLA-DRB1*07 and DRB1*09 haplotypes as well as DRB1*04 at onset of type 1 diabetes: the possible role of HLA-DQA in autoimmunity to IA-2. Williams AJ, et al. Diabetologia, 2008 Aug. PMID 18504544.
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