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Goat Anti-IA2 Antibody

Peptide-affinity purified goat antibody

  • WB - Goat Anti-IA2 Antibody AF1548a
    AF1548a (0.5 µg/ml) staining of NIH 3T3 lysate (35 µg protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q16849
Other Accession NP_002837, 5798, 19275 (mouse), 116660 (rat)
Reactivity Mouse
Predicted Human, Rat
Host Goat
Clonality Polyclonal
Concentration 100ug/200ul
Isotype IgG
Calculated MW 105848 Da
Additional Information
Gene ID 5798
Other Names Receptor-type tyrosine-protein phosphatase-like N, R-PTP-N, Islet cell antigen 512, ICA 512, Islet cell autoantigen 3, PTP IA-2, PTPRN, ICA3, ICA512
Format 0.5 mg IgG/ml in Tris saline (20mM Tris pH7.3, 150mM NaCl), 0.02% sodium azide, with 0.5% bovine serum albumin
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsGoat Anti-IA2 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Synonyms ICA3, ICA512
Function Implicated in neuroendocrine secretory processes. May be involved in processes specific for neurosecretory granules, such as their biogenesis, trafficking or regulated exocytosis or may have a general role in neuroendocrine functions. Seems to lack intrinsic enzyme activity. May play a role in the regulation of secretory granules via its interaction with SNTB2.
Cellular Location Membrane; Single-pass type I membrane protein. Note=Neuroendocrine secretory granules
Tissue Location Expression is restricted to neuroendocrine cells. Found in pancreas, brain and pituitary
Research Areas
Citations (0)

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The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP possesses an extracellular region, a single transmembrane region, and a single catalytic domain, and thus represents a receptor-type PTP. This PTP was found to be an autoantigen that is reactive with insulin-dependent diabetes mellitus (IDDM) patient sera, and thus may be a potential target of autoimmunity in diabetes mellitus.


Evidence for molecular mimicry between human T cell epitopes in rotavirus and pancreatic islet autoantigens. Honeyman MC, et al. J Immunol, 2010 Feb 15. PMID 20083660.
Triple chimeric islet autoantigen IA2-ZnT8WR to facilitate islet autoantibody determination. Yu L, et al. J Immunol Methods, 2010 Feb 28. PMID 20035758.
Autoantibodies and associated T-cell responses to determinants within the 831-860 region of the autoantigen IA-2 in Type 1 diabetes. Weenink SM, et al. J Autoimmun, 2009 Sep. PMID 19447008.
A new luminescence assay for autoantibodies to mammalian cell-prepared insulinoma-associated protein 2. Burbelo PD, et al. Diabetes Care, 2008 Sep. PMID 18535195.
Autoantibodies to islet antigen-2 are associated with HLA-DRB1*07 and DRB1*09 haplotypes as well as DRB1*04 at onset of type 1 diabetes: the possible role of HLA-DQA in autoimmunity to IA-2. Williams AJ, et al. Diabetologia, 2008 Aug. PMID 18504544.

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$ 325.00
Cat# AF1548a
(40 western blots)
Availability: 7-10 days
Bulk Size
Seasonal Special on Bulk Order
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