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Goat Anti-IBP / DEF6 Antibody

Peptide-affinity purified goat antibody

  • WB - Goat Anti-IBP / DEF6 Antibody AF1549a
    AF1549a (1 µg/ml) staining of Human Thymus lysate (35 µg protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q9H4E7
Other Accession NP_071330, 50619, 23853 (mouse)
Reactivity Human
Predicted Mouse, Rat, Pig, Dog, Cow
Host Goat
Clonality Polyclonal
Concentration 100ug/200ul
Isotype IgG
Calculated MW 73910 Da
Additional Information
Gene ID 50619
Other Names Differentially expressed in FDCP 6 homolog, DEF-6, IRF4-binding protein, DEF6, IBP
Format 0.5 mg IgG/ml in Tris saline (20mM Tris pH7.3, 150mM NaCl), 0.02% sodium azide, with 0.5% bovine serum albumin
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsGoat Anti-IBP / DEF6 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name DEF6
Synonyms IBP
Function Phosphatidylinositol 3,4,5-trisphosphate-dependent guanine nucleotide exchange factor (GEF) which plays a role in the activation of Rho GTPases RAC1, RhoA and CDC42. Can regulate cell morphology in cooperation with activated RAC1. Plays a role in Th2 (T helper cells) development and/or activation, perhaps by interfering with ZAP70 signaling (By similarity).
Cellular Location Cytoplasm. Cell membrane. Nucleus. Note=Recruited to the plasma membrane upon binding phosphatidylinositol 3,4,5-trisphosphate
Tissue Location Broadly expressed in the immune system and can be detected in T and B-cells.
Research Areas
Citations (0)

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DEF6, or IBP, is a guanine nucleotide exchange factor (GEF) for RAC (MIM 602048) and CDC42 (MIM 116952) that is highly expressed in B and T cells (Gupta et al., 2003 [PubMed 12923183]).


The role of height-associated loci identified in genome wide association studies in the determination of pediatric stature. Zhao J, et al. BMC Med Genet, 2010 Jun 14. PMID 20546612.
Polymorphisms in innate immunity genes and risk of childhood leukemia. Han S, et al. Hum Immunol, 2010 Jul. PMID 20438785.
Risk of meningioma and common variation in genes related to innate immunity. Rajaraman P, et al. Cancer Epidemiol Biomarkers Prev, 2010 May. PMID 20406964.
Overexpression of the Interferon regulatory factor 4-binding protein in human colorectal cancer and its clinical significance. Zhang Z, et al. Cancer Epidemiol, 2009 Aug. PMID 19679060.
Common variation in genes related to innate immunity and risk of adult glioma. Rajaraman P, et al. Cancer Epidemiol Biomarkers Prev, 2009 May. PMID 19423540.

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$ 325.00
Cat# AF1549a
(40 western blots)
Availability: 7-10 days
Bulk Size
Seasonal Special on Bulk Order
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