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Goat Anti-IFT88 / Polaris Antibody

Peptide-affinity purified goat antibody

     
  • IHC - Goat Anti-IFT88 / Polaris Antibody AF1555a
    AF1555a (3 µg/ml) staining of paraffin embedded Human Kidney. Microwaved antigen retrieval with Tris/EDTA buffer pH9, HRP-staining.
  • SPECIFICATION
  • CITATIONS
  • PROTOCOLS
  • BACKGROUND
Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
IHC, IF, E
Primary Accession Q13099
Other Accession NP_006522, 8100, 21821 (mouse), 305918 (rat)
Reactivity Human, Mouse
Predicted Rat, Dog
Host Goat
Clonality Polyclonal
Concentration 100ug/200ul
Isotype IgG
Additional Information
Other Names Intraflagellar transport protein 88 homolog, Recessive polycystic kidney disease protein Tg737 homolog, Tetratricopeptide repeat protein 10, TPR repeat protein 10, IFT88, TG737, TTC10
Format 0.5 mg IgG/ml in Tris saline (20mM Tris pH7.3, 150mM NaCl), 0.02% sodium azide, with 0.5% bovine serum albumin
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsGoat Anti-IFT88 / Polaris Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name IFT88
Synonyms TG737, TTC10
Function Involved in primary cilium biogenesis. Also involved in autophagy since it is required for trafficking of ATG16L and the expansion of the autophagic compartment.
Cellular Location Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole {ECO:0000250|UniProtKB:Q61371}. Cell projection, cilium. Cytoplasm, cytoskeleton, cilium basal body
Tissue Location Expressed in the heart, brain, liver, lung, kidney, skeletal muscle and pancreas EMBL; U20362; AAA86720.1; -; mRNA EMBL; AK300769; BAG62434.1; -; mRNA EMBL; AL161772; -; NOT_ANNOTATED_CDS; Genomic_DNA EMBL; AL590096; -; NOT_ANNOTATED_CDS; Genomic_DNA EMBL; CH471075; EAX08272.1; -; Genomic_DNA EMBL; BC030776; AAH30776.2; -; mRNA CCDS; CCDS31944.1; -. [Q13099-1] CCDS; CCDS31945.1; -. [Q13099-2] RefSeq; NP_001305420.1; NM_001318491.1 RefSeq; NP_001305422.1; NM_001318493.1. [Q13099-1] RefSeq; NP_783195.2; NM_175605.4. [Q13099-1] RefSeq; XP_005266610.1; XM_005266553.2 RefSeq; XP_011533543.1; XM_011535241.2 RefSeq; XP_016876247.1; XM_017020758.1. [Q13099-3] UniGene; Hs.187376; - ProteinModelPortal; Q13099; - BioGrid; 113771; 36 CORUM; Q13099; - IntAct; Q13099; 52 STRING; 9606.ENSP00000323580; - iPTMnet; Q13099; - PhosphoSitePlus; Q13099; - BioMuta; IFT88; - DMDM; 206729873; - EPD; Q13099; - MaxQB; Q13099; - PaxDb; Q13099; - PeptideAtlas; Q13099; - PRIDE; Q13099; - ProteomicsDB; 59151; - ProteomicsDB; 59152; -. [Q13099-2] ProteomicsDB; 59153; -. [Q13099-3] DNASU; 8100; - Ensembl; ENST00000319980; ENSP00000323580; ENSG00000032742. [Q13099-1] Ensembl; ENST00000351808; ENSP00000261632; ENSG00000032742. [Q13099-2] GeneID; 8100; - KEGG; hsa:8100; - UCSC; uc001unh.4; human. [Q13099-1] CTD; 8100; - DisGeNET; 8100; - EuPathDB; HostDB:ENSG00000032742.17; - GeneCards; IFT88; - HGNC; HGNC:20606; IFT88 MIM; 600595; gene neXtProt; NX_Q13099; - OpenTargets; ENSG00000032742; - PharmGKB; PA134991804; - eggNOG; KOG2003; Eukaryota eggNOG; ENOG410XPPW; LUCA GeneTree; ENSGT00390000015473; - HOGENOM; HOG000258203; - HOVERGEN; HBG059328; - InParanoid; Q13099; - KO; K16474; - OMA; PLGQSRG; - OrthoDB; EOG091G08VB; - PhylomeDB; Q13099; - TreeFam; TF313218; - Reactome; R-HSA-5610787; Hedgehog 'off' state Reactome; R-HSA-5620924; Intraflagellar transport SIGNOR; Q13099; - ChiTaRS; IFT88; human GeneWiki; IFT88; - GenomeRNAi; 8100; - PRO; PR:Q13099; - Proteomes; UP000005640; Chromosome 13 Bgee; ENSG00000032742; - CleanEx; HS_IFT88; - ExpressionAtlas; Q13099; baseline and differential Genevisible; Q13099; HS GO; GO:0005814; C:centriole; IDA:UniProtKB GO; GO:0036064; C:ciliary basal body; IDA:UniProtKB GO; GO:0097542; C:ciliary tip; TAS:Reactome GO; GO:0005929; C:cilium; IDA:UniProtKB GO; GO:0030992; C:intraciliary transport particle B; ISS:UniProtKB GO; GO:0031514; C:motile cilium; ISS:BHF-UCL GO; GO:0060271; P:cilium assembly; ISS:UniProtKB GO; GO:0035735; P:intraciliary transport involved in cilium assembly; TAS:Reactome GO; GO:2000785; P:regulation of autophagosome assembly; ISS:UniProtKB GO; GO:1902017; P:regulation of cilium assembly; ISS:UniProtKB Gene3D; 1.25.40.10; -; 3 InterPro; IPR006597; Sel1-like InterPro; IPR013026; TPR-contain_dom InterPro; IPR011990; TPR-like_helical_dom_sf InterPro; IPR019734; TPR_repeat Pfam; PF13174; TPR_6; 1 Pfam; PF13181; TPR_8; 1 SMART; SM00671; SEL1; 4 SMART; SM00028; TPR; 11 SUPFAM; SSF48452; SSF48452; 2 PROSITE; PS50005; TPR; 9 PROSITE; PS50293; TPR_REGION; 2 1: Evidence at protein level; Alternative splicing; Cell projection; Cilium; Cilium biogenesis/degradation; Complete proteome; Cytoplasm; Cytoskeleton; Polymorphism; Reference proteome; Repeat; TPR repeat CHAIN 1 833 Intraflagellar transport protein 88 homolog /FTId=PRO_0000106391 REPEAT 206 239 TPR 1 REPEAT 242 275 TPR 2 REPEAT 281 314 TPR 3 REPEAT 316 347 TPR 4 REPEAT 424 457 TPR 5 REPEAT 459 492 TPR 6 REPEAT 493 526 TPR 7 REPEAT 527 560 TPR 8 REPEAT 561 594 TPR 9 REPEAT 595 628 TPR 10 REPEAT 629 662 TPR 11 REPEAT 663 696 TPR 12 VAR_SEQ 1 9 Missing (in isoform 2) /FTId=VSP_035429 VAR_SEQ 61 79 Missing (in isoform 3) /FTId=VSP_040620 VARIANT 383 383 M -> I (in dbSNP:rs2442455) /FTId=VAR_046464 VARIANT 455 455 S -> N (in dbSNP:rs9509307) /FTId=VAR_046465 VARIANT 671 671 S -> G (in dbSNP:rs9552254) /FTId=VAR_046466 CONFLICT 210 210 F -> S (in Ref. 1; AAA86720) CONFLICT 335 335 K -> E (in Ref. 5; AAH30776) CONFLICT 388 388 I -> V (in Ref. 5; AAH30776) CONFLICT 389 389 M -> T (in Ref. 1; AAA86720) CONFLICT 407 407 Y -> C (in Ref. 1; AAA86720) CONFLICT 608 608 E -> G (in Ref. 5; AAH30776) SEQUENCE 833 AA; 94270 MW; 383887C9D79AF0DA CRC64; MKFTNTKVQM MQNVHLAPET DEDDLYSGYN DYNPIYDIEE LENDAAFQQA VRTSHGRRPP ITAKISSTAV TRPIATGYGS KTSLASSIGR PMTGAIQDGV TRPMTAVRAA GFTKAALRGS AFDPLSQSRG PASPLEAKKK DSPEEKIKQL EKEVNELVEE SCIANSCGDL KLALEKAKDA GRKERVLVRQ REQVTTPENI NLDLTYSVLF NLASQYSVNE MYAEALNTYQ VIVKNKMFSN AGILKMNMGN IYLKQRNYSK AIKFYRMALD QVPSVNKQMR IKIMQNIGVT FIQAGQYSDA INSYEHIMSM APNLKAGYNL TICYFAIGDR EKMKKAFQKL ITVPLEIDED KYISPSDDPH TNLVTEAIKN DHLRQMERER KAMAEKYIMT SAKLIAPVIE TSFAAGYDWC VEVVKASQYV ELANDLEINK AVTYLRQKDY NQAVEILKVL EKKDSRVKSA AATNLSALYY MGKDFAQASS YADIAVNSDR YNPAALTNKG NTVFANGDYE KAAEFYKEAL RNDSSCTEAL YNIGLTYEKL NRLDEALDCF LKLHAILRNS AEVLYQIANI YELMENPSQA IEWLMQVVSV IPTDPQVLSK LGELYDREGD KSQAFQYYYE SYRYFPCNIE VIEWLGAYYI DTQFWEKAIQ YFERASLIQP TQVKWQLMVA SCFRRSGNYQ KALDTYKDTH RKFPENVECL RFLVRLCTDL GLKDAQEYAR KLKRLEKMKE IREQRIKSGR DGSGGSRGKR EGSASGDSGQ NYSASSKGER LSARLRALPG TNEPYESSSN KEIDASYVDP LGPQIERPKT AAKKRIDEDD FADEELGDDL LPE
Research Areas
Citations (0)

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Background

This gene encodes a member of the tetratrico peptide repeat (TPR) family. Mutations of a similar gene in mouse can cause polycystic kidney disease. Two transcript variants encoding distinct isoforms have been identified for this gene.

References

Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. Rose JE, et al. Mol Med, 2010 Jul-Aug. PMID 20379614.
The intraflagellar transport component IFT88/polaris is a centrosomal protein regulating G1-S transition in non-ciliated cells. Robert A, et al. J Cell Sci, 2007 Feb 15. PMID 17264151.
RPGR-ORF15, which is mutated in retinitis pigmentosa, associates with SMC1, SMC3, and microtubule transport proteins. Khanna H, et al. J Biol Chem, 2005 Sep 30. PMID 16043481.
Analysis of a high-throughput yeast two-hybrid system and its use to predict the function of intracellular proteins encoded within the human MHC class III region. Lehner B, et al. Genomics, 2004 Jan. PMID 14667819.
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932.

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$ 335.00
Cat# AF1555a
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