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Goat Anti-IMPDH2 Antibody

Peptide-affinity purified goat antibody

  • WB - Goat Anti-IMPDH2 Antibody AF1565a
    AF1565a (1 µg/ml) staining of Human Skeletal Muscle lysate (35 µg protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession P12268
Other Accession NP_000875, 3615
Reactivity Human
Host Goat
Clonality Polyclonal
Concentration 0.5mg/ml
Isotype IgG
Calculated MW 55805 Da
Additional Information
Gene ID 3615
Other Names Inosine-5'-monophosphate dehydrogenase 2 {ECO:0000255|HAMAP-Rule:MF_03156}, IMP dehydrogenase 2 {ECO:0000255|HAMAP-Rule:MF_03156}, IMPD 2 {ECO:0000255|HAMAP-Rule:MF_03156}, IMPDH 2 {ECO:0000255|HAMAP-Rule:MF_03156}, {ECO:0000255|HAMAP-Rule:MF_03156}, IMPDH-II, IMPDH2 {ECO:0000255|HAMAP-Rule:MF_03156}, IMPD2
Format 0.5 mg IgG/ml in Tris saline (20mM Tris pH7.3, 150mM NaCl), 0.02% sodium azide, with 0.5% bovine serum albumin
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsGoat Anti-IMPDH2 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name IMPDH2 {ECO:0000255|HAMAP-Rule:MF_03156}
Synonyms IMPD2
Function Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Could also have a single-stranded nucleic acid-binding activity and could play a role in RNA and/or DNA metabolism. It may also have a role in the development of malignancy and the growth progression of some tumors.
Cellular Location Cytoplasm {ECO:0000255|HAMAP-Rule:MF_03156, ECO:0000269|PubMed:14766016}. Nucleus {ECO:0000255|HAMAP- Rule:MF_03156, ECO:0000269|PubMed:14766016}
Tissue Location IMP type I is the main species in normal leukocytes and type II predominates over type I in the tumor
Research Areas
Citations (0)

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This gene encodes the rate-limiting enzyme in the de novo guanine nucleotide biosynthesis. It is thus involved in maintaining cellular guanine deoxy- and ribonucleotide pools needed for DNA and RNA synthesis. The encoded protein catalyzes the NAD-dependent oxidation of inosine-5'-monophosphate into xanthine-5'-monophosphate, which is then converted into guanosine-5'-monophosphate. This gene is up-regulated in some neoplasms, suggesting it may play a role in malignant transformation.


Polymorphisms in type I and II inosine monophosphate dehydrogenase genes and association with clinical outcome in patients on mycophenolate mofetil. Gensburger O, et al. Pharmacogenet Genomics, 2010 Sep. PMID 20679962. Genetic polymorphisms influence mycophenolate mofetil-related adverse events in pediatric heart transplant patients. Ohmann EL, et al. J Heart Lung Transplant, 2010 May. PMID 20061166. Genetic variations in the HGPRT, ITPA, IMPDH1, IMPDH2, and GMPS genes in Japanese individuals. Kudo M, et al. Drug Metab Pharmacokinet, 2009. PMID 20045992. IMPDH2 genetic polymorphism: a promoter single-nucleotide polymorphism disrupts a cyclic adenosine monophosphate responsive element. Garat A, et al. Genet Test Mol Biomarkers, 2009 Dec. PMID 19810816. An inosine 5'-monophosphate dehydrogenase 2 single-nucleotide polymorphism impairs the effect of mycophenolic acid. Winnicki W, et al. Pharmacogenomics J, 2010 Feb. PMID 19770842.

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$ 325.00
Cat# AF1565a
(40 western blots)
Availability: 7-10 days
Bulk Size
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