|Application ||WB, IHC, E, IP, CHIP|
|Other Accession||NP_001092099, 3663|
|Predicted||Mouse, Rat, Cow|
|Calculated MW||56044 Da|
|Other Names||Interferon regulatory factor 5, IRF-5, IRF5|
|Format||0.5 mg IgG/ml in Tris saline (20mM Tris pH7.3, 150mM NaCl), 0.02% sodium azide, with 0.5% bovine serum albumin|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||Goat Anti-IRF5 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Transcription factor involved in the induction of interferons IFNA and INFB and inflammatory cytokines upon virus infection. Activated by TLR7 or TLR8 signaling.|
|Cellular Location||Cytoplasm. Nucleus. Note=Shuttles between the nucleus and the cytoplasm|
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Provided below are standard protocols that you may find useful for product applications.
This gene encodes a member of the interferon regulatory factor (IRF) family, a group of transcription factors with diverse roles, including virus-mediated activation of interferon, and modulation of cell growth, differentiation, apoptosis, and immune system activity. Members of the IRF family are characterized by a conserved N-terminal DNA-binding domain containing tryptophan (W) repeats. Multiple transcript variants encoding different isoforms have been found for this gene, and a 30-nt indel polymorphism (SNP rs60344245) can result in loss of a 10-aa segment.
Genome-wide meta-analyses identify three loci associated with primary biliary cirrhosis. Liu X, et al. Nat Genet, 2010 Aug. PMID 20639880.
Variants at IRF5-TNPO3, 17q12-21 and MMEL1 are associated with primary biliary cirrhosis. Hirschfield GM, et al. Nat Genet, 2010 Aug. PMID 20639879.
Variation at the NFATC2 Locus Increases the Risk of Thiazolinedinedione-Induced Edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) Study. Bailey SD, et al. Diabetes Care, 2010 Jul 13. PMID 20628086.
Genetic Differences between Five European Populations. Moskvina V, et al. Hum Hered, 2010 Jul 8. PMID 20616560.
Dengue hemorrhagic fever is associated with polymorphisms in JAK1. Silva LK, et al. Eur J Hum Genet, 2010 Jun 30. PMID 20588308.
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