|Application ||WB, E|
|Other Accession||NP_067042, 58494, 67374 (mouse), 619374 (rat)|
|Predicted||Mouse, Rat, Dog, Cow|
|Calculated MW||33207 Da|
|Other Names||Junctional adhesion molecule B, JAM-B, Junctional adhesion molecule 2, JAM-2, Vascular endothelial junction-associated molecule, VE-JAM, CD322, JAM2, C21orf43, VEJAM|
|Format||0.5 mg IgG/ml in Tris saline (20mM Tris pH7.3, 150mM NaCl), 0.02% sodium azide, with 0.5% bovine serum albumin|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||Goat Anti-JAM2 / JAMB / CD322 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||May play a role in the processes of lymphocyte homing to secondary lymphoid organs.|
|Cellular Location||Cell junction, tight junction. Cell membrane; Single-pass type I membrane protein. Note=Localized at tight junctions of both epithelial and endothelial cells.|
|Tissue Location||Highest expression in the heart, placenta, lung, foreskin and lymph node. Prominently expressed on high endothelial venules, also present on the endothelia of other vessels. Localized to the intercellular boundaries of high endothelial cells.|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Tight junctions represent one mode of cell-to-cell adhesion in epithelial or endothelial cell sheets, forming continuous seals around cells and serving as a physical barrier to prevent solutes and water from passing freely through the paracellular space. The protein encoded by this immunoglobulin superfamily gene member is localized in the tight junctions between high endothelial cells. It acts as an adhesive ligand for interacting with a variety of immune cell types and may play a role in lymphocyte homing to secondary lymphoid organs.
A genome-wide study of common SNPs and CNVs in cognitive performance in the CANTAB. Need AC, et al. Hum Mol Genet, 2009 Dec 1. PMID 19734545.
Expression of junctional adhesion molecules on the human lymphatic endothelium. Ueki T, et al. Microvasc Res, 2008 Mar. PMID 17822725.
The role of junctional adhesion molecules in vascular inflammation. Weber C, et al. Nat Rev Immunol, 2007 Jun. PMID 17525755.
A distinct PAR complex associates physically with VE-cadherin in vertebrate endothelial cells. Iden S, et al. EMBO Rep, 2006 Dec. PMID 17057644.
The LIFEdb database in 2006. Mehrle A, et al. Nucleic Acids Res, 2006 Jan 1. PMID 16381901.
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