|Application ||WB, IHC, E|
|Other Accession||NP_003938, 8997, 545156 (mouse), 84009 (rat)|
|Reactivity||Human, Mouse, Rat|
|Calculated MW||340174 Da|
|Other Names||Kalirin, 188.8.131.52, Huntingtin-associated protein-interacting protein, Protein Duo, Serine/threonine-protein kinase with Dbl- and pleckstrin homology domain, KALRN, DUET, DUO, HAPIP, TRAD|
|Format||0.5 mg IgG/ml in Tris saline (20mM Tris pH7.3, 150mM NaCl), 0.02% sodium azide, with 0.5% bovine serum albumin|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||Goat Anti-Kalirin (isoform 2) Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Synonyms||DUET, DUO, HAPIP, TRAD|
|Function||Promotes the exchange of GDP by GTP. Activates specific Rho GTPase family members, thereby inducing various signaling mechanisms that regulate neuronal shape, growth, and plasticity, through their effects on the actin cytoskeleton. Induces lamellipodia independent of its GEF activity.|
|Cellular Location||Cytoplasm. Cytoplasm, cytoskeleton Note=Associated with the cytoskeleton|
|Tissue Location||Isoform 2 is brain specific. Highly expressed in cerebral cortex, putamen, amygdala, hippocampus and caudate nucleus. Weakly expressed in brain stem and cerebellum. Isoform 4 is expressed in skeletal muscle.|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Huntington's disease (HD), a neurodegenerative disorder characterized by loss of striatal neurons, is caused by an expansion of a polyglutamine tract in the HD protein huntingtin. This gene encodes a protein that interacts with the huntingtin-associated protein 1, which is a huntingtin binding protein that may function in vesicle trafficking. Alternatively spliced transcript variants encoding different isoforms have been described.
Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. Rose JE, et al. Mol Med, 2010 Jul-Aug. PMID 20379614.
Kalirin: a novel genetic risk factor for ischemic stroke. Krug T, et al. Hum Genet, 2010 Mar. PMID 20107840.
Inherited genetic variant predisposes to aggressive but not indolent prostate cancer. Xu J, et al. Proc Natl Acad Sci U S A, 2010 Feb 2. PMID 20080650.
Identification of SH3 domain interaction partners of human FasL (CD178) by phage display screening. Voss M, et al. BMC Immunol, 2009 Oct 6. PMID 19807924.
Validation study of genetic associations with coronary artery disease on chromosome 3q13-21 and potential effect modification by smoking. Horne BD, et al. Ann Hum Genet, 2009 Nov. PMID 19706030.
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