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Goat Anti-KCC3 / SLC12A6 Antibody

Peptide-affinity purified goat antibody

  • WB - Goat Anti-KCC3 / SLC12A6 Antibody AF1583a
    AF1583a (0.1 µg/ml) staining of Human Heart lysate (35 µg protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.
  • IHC - Goat Anti-KCC3 / SLC12A6 Antibody AF1583a
    AF1583a (2.5 µg/ml) staining of paraffin embedded Human Heart. Steamed antigen retrieval with citrate buffer pH 6, AP-staining.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q9UHW9
Other Accession NP_598408, 9990
Reactivity Human
Host Goat
Clonality Polyclonal
Concentration 100ug/200ul
Isotype IgG
Calculated MW 127617 Da
Additional Information
Gene ID 9990
Other Names Solute carrier family 12 member 6, Electroneutral potassium-chloride cotransporter 3, K-Cl cotransporter 3, SLC12A6, KCC3
Format 0.5 mg IgG/ml in Tris saline (20mM Tris pH7.3, 150mM NaCl), 0.02% sodium azide, with 0.5% bovine serum albumin
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsGoat Anti-KCC3 / SLC12A6 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name SLC12A6
Synonyms KCC3
Function Mediates electroneutral potassium-chloride cotransport. May be activated by cell swelling. May contribute to cell volume homeostasis in single cells.
Cellular Location Basolateral cell membrane; Multi-pass membrane protein
Tissue Location Highly expressed in heart, brain and kidney. Detected at lower levels in skeletal muscle, placenta, lung and pancreas. Detected in umbilical vein endothelial cells. Isoform 2 is more abundant in kidney. Isoform 5 is testis specific Expressed in the proximal tubule of the kidney (at protein level)
Research Areas
Citations (0)

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This gene is a member of the K-Cl cotransporter (KCC) family. K-Cl cotransporters are integral membrane proteins that lower intracellular chloride concentrations below the electrochemical equilibrium potential. The proteins encoded by this gene are activated by cell swelling induced by hypotonic conditions. Alternate splicing results in multiple transcript variants encoding different isoforms. Mutations in this gene are associated with agenesis of the corpus callosum with peripheral neuropathy.


Andermann syndrome can be a phenocopy of hereditary motor and sensory neuropathy--report of a discordant sibship with a compound heterozygous mutation of the KCC3 gene. Rudnik-Sch枚neborn S, et al. Neuropediatrics, 2009 Jun. PMID 20020398.
Sites of regulated phosphorylation that control K-Cl cotransporter activity. Rinehart J, et al. Cell, 2009 Aug 7. PMID 19665974.
A common variant in DRD3 receptor is associated with autism spectrum disorder. de Krom M, et al. Biol Psychiatry, 2009 Apr 1. PMID 19058789.
HMSN/ACC truncation mutations disrupt brain-type creatine kinase-dependant activation of K+/Cl- co-transporter 3. Salin-Cantegrel A, et al. Hum Mol Genet, 2008 Sep 1. PMID 18566107.
Functional analysis of a potassium-chloride co-transporter 3 (SLC12A6) promoter polymorphism leading to an additional DNA methylation site. Moser D, et al. Neuropsychopharmacology, 2009 Jan. PMID 18536702.

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$ 325.00
Cat# AF1583a
(40 western blots)
Availability: 7-10 days
Bulk Size
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