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Goat Anti-KPNA4 / IPOA3 Antibody

Peptide-affinity purified goat antibody

  • WB - Goat Anti-KPNA4 / IPOA3 Antibody AF1604a
    AF1604a staining (0.5 µg/ml) of Human Testis lysate (RIPA buffer, 35 µg total protein per lane). Primary incubated for 1 hour. Detected by western blot using chemiluminescence.
  • IHC - Goat Anti-KPNA4 / IPOA3 Antibody AF1604a
    AF1604a (3 µg/ml) staining of paraffin embedded Human Testis. Microwaved antigen retrieval with citrate buffer pH 6, HRP-staining.
  • IHC - Goat Anti-KPNA4 / IPOA3 Antibody AF1604a
    AF1604a (5 µg/ml) staining of paraffin embedded Human Small Intestine. Steamed antigen retrieval with citrate buffer pH 6, AP-staining.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession O00629
Other Accession NP_002259, 3840
Reactivity Human, Mouse
Predicted Rat, Dog, Cow
Host Goat
Clonality Polyclonal
Concentration 100ug/200ul
Isotype IgG
Calculated MW 57887 Da
Additional Information
Gene ID 3840
Other Names Importin subunit alpha-3, Importin alpha Q1, Qip1, Karyopherin subunit alpha-4, KPNA4, QIP1
Format 0.5 mg IgG/ml in Tris saline (20mM Tris pH7.3, 150mM NaCl), 0.02% sodium azide, with 0.5% bovine serum albumin
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsGoat Anti-KPNA4 / IPOA3 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name KPNA4
Synonyms QIP1
Function Functions in nuclear protein import as an adapter protein for nuclear receptor KPNB1. Binds specifically and directly to substrates containing either a simple or bipartite NLS motif. Docking of the importin/substrate complex to the nuclear pore complex (NPC) is mediated by KPNB1 through binding to nucleoporin FxFG repeats and the complex is subsequently translocated through the pore by an energy requiring, Ran- dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to importin-beta and the three components separate and importin-alpha and -beta are re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran from importin. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. In vitro, mediates the nuclear import of human cytomegalovirus UL84 by recognizing a non- classical NLS. In vitro, mediates the nuclear import of human cytomegalovirus UL84 by recognizing a non-classical NLS.
Cellular Location Cytoplasm. Nucleus
Tissue Location Highly expressed in testis, ovary, small intestine, heart, skeletal muscle, lung and pancreas, but barely detectable in kidney, thymus, colon and peripheral blood leukocytes
Research Areas
Citations (0)

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The nuclear import of karyophilic proteins is directed by short amino acid sequences termed nuclear localization signals (NLSs). Karyopherins, or importins, are cytoplasmic proteins that recognize NLSs and dock NLS-containing proteins to the nuclear pore complex. The protein encoded by this gene shares the sequence similarity with Xenopus importin-alpha and Saccharomyces cerevisiae Srp1. This protein is found to interact with the NLSs of DNA helicase Q1 and SV40 T antigen.


Importin alpha3 interacts with HIV-1 integrase and contributes to HIV-1 nuclear import and replication. Ao Z, et al. J Virol, 2010 Sep. PMID 20554775.
Common importin alpha specificity for papillomavirus E2 proteins. Bian XL, et al. Virus Res, 2010 Jun. PMID 20193720.
Stress-mediated nuclear stabilization of p53 is regulated by ubiquitination and importin-alpha3 binding. Marchenko ND, et al. Cell Death Differ, 2010 Feb. PMID 19927155.
Prohibitin inhibits tumor necrosis factor alpha-induced nuclear factor-kappa B nuclear translocation via the novel mechanism of decreasing importin alpha3 expression. Theiss AL, et al. Mol Biol Cell, 2009 Oct. PMID 19710421.
Plasmodium circumsporozoite protein promotes the development of the liver stages of the parasite. Singh AP, et al. Cell, 2007 Nov 2. PMID 17981117.

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$ 325.00
Cat# AF1604a
(40 western blots)
Availability: 7-10 days
Bulk Size
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