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KU70 / XRCC6 AntibodyPeptide-affinity purified goat antibody
| Country | United States
Ordering Information
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| Catalog # | Size | Availability | Price | |
| AF1607a | 0.1mg 400 ul | 7-10 days | $ 325.00 | DISCONTINED INQUIRE CLICK INQUIRE Add to cart |
- Specification
- Citiations : 0
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KU70 / XRCC6 Antibody - Product info | |
| Other Accession | NP_001460 |
| Reactivity | Human |
| Concentration | 100ug/200ul |
| Isotype | IgG |
KU70 / XRCC6 Antibody - Additional info | |
| Other Names XRCC6; KU70; X-ray repair complementing defective repair in Chinese hamster cells 6 (Ku autoantigen, 70kDa) ; CTC75; CTCBF; G22P1; ML8; TLAA ; ATP-dependent DNA helicase II, 70 kDa subunit; CTC box binding factor 75 kDa subunit; Ku autoantigen p70 subunit; OTTHUMP00000028581; thyroid autoantigen 70kD (Ku antigen); thyroid autoantigen 70kDa (Ku antigen); thyroid-lupus autoantigen p70 | |
| Format 0.5 mg IgG/ml in Tris saline (20mM Tris pH7.3, 150mM NaCl), 0.02% sodium azide, with 0.5% bovine serum albumin | |
| Storage Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. | |
| Precautions KU70 / XRCC6 Antibody is for research use only and not for use in diagnostic or therapeutic procedures. | |
KU70 / XRCC6 Antibody - Application data
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AF1607a (0.1 µg/ml) staining of HeLa cell lysate (35 µg protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.
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HEK293 overexpressing KU70 (RC204048) and probed with AF1607a (mock transfection in first lane), tested by Origene.
KU70 / XRCC6 Antibody - Related products
AP5089b: XRCC6 Antibody (C-term)
AP5089c: XRCC6 Antibody (Center)
AP6775a: Ku70 Antibody (N-term)
AP6775c: Ku70 Antibody (Center)
RI15763: XRCC6 predesign siRNA
LY10971a: XRCC6 Over-expression Lysate
BP5089b: XRCC6 Antibody (C-term) Blocking Peptide
BP5089c: XRCC6 Antibody (Center) Blocking peptide
BP6775a: Ku70 Antibody (N-term) Blocking Peptide
BP6775c: Ku70 Antibody (Center) Blocking Peptide
AT2136a: G22P1 Antibody (monoclonal) (M01)
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BACKGROUND
The p70/p80 autoantigen is a nuclear complex consisting of two subunits with molecular masses of approximately 70 and 80 kDa. The complex functions as a single-stranded DNA-dependent ATP-dependent helicase. The complex may be involved in the repair of nonhomologous DNA ends such as that required for double-strand break repair, transposition, and V(D)J recombination. High levels of autoantibodies to p70 and p80 have been found in some patients with systemic lupus erythematosus.
REFERENCES
Variation at the NFATC2 Locus Increases the Risk of Thiazolinedinedione-Induced Edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) Study. Bailey SD, et al. Diabetes Care, 2010 Jul 13. PMID 20628086. Gamma-Radiation Sensitivity and Polymorphisms in RAD51L1 Modulate Glioma Risk. Liu Y, et al. Carcinogenesis, 2010 Jul 7. PMID 20610542. Ku70 corrupts DNA repair in the absence of the Fanconi anemia pathway. Pace P, et al. Science, 2010 Jul 9. PMID 20538911. Variation within DNA repair pathway genes and risk of multiple sclerosis. Briggs FB, et al. Am J Epidemiol, 2010 Jul 15. PMID 20522537. Analysis of the polymorphisms in non-homologous DNA end joining (NHEJ) gene Ku70 and Ligase IV in sporadic breast cancer in women. Sobczuk A, et al. Pol J Pathol, 2010. PMID 20496270.
