|Application ||WB, E|
|Other Accession||NP_006139, 3927|
|Calculated MW||29717 Da|
|Other Names||LIM and SH3 domain protein 1, LASP-1, Metastatic lymph node gene 50 protein, MLN 50, LASP1, MLN50|
|Format||0.5 mg IgG/ml in Tris saline (20mM Tris pH7.3, 150mM NaCl), 0.02% sodium azide, with 0.5% bovine serum albumin|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||Goat Anti-LASP1 (internal region) Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Plays an important role in the regulation of dynamic actin-based, cytoskeletal activities. Agonist-dependent changes in LASP1 phosphorylation may also serve to regulate actin-associated ion transport activities, not only in the parietal cell but also in certain other F-actin-rich secretory epithelial cell types (By similarity).|
|Cellular Location||Cytoplasm, cell cortex. Cytoplasm, cytoskeleton. Note=Associated with the F- actin rich cortical cytoskeleton.|
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Provided below are standard protocols that you may find useful for product applications.
This gene encodes a member of a LIM protein subfamily characterized by a LIM motif and a domain of Src homology region 3. The encoded protein functions as an actin-binding protein and possibly in cytoskeletal organization.
Nuclear localisation of LASP-1 correlates with poor long-term survival in female breast cancer. Frietsch JJ, et al. Br J Cancer, 2010 May 25. PMID 20461080.
Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. Rose JE, et al. Mol Med, 2010 Jul-Aug. PMID 20379614.
Integrin-dependent translocation of LASP-1 to the cytoskeleton of activated platelets correlates with LASP-1 phosphorylation at tyrosine 171 by Src-kinase. Traenka J, et al. Thromb Haemost, 2009 Sep. PMID 19718473.
Proteomic identification of LASP-1 down-regulation after RNAi urokinase silencing in human hepatocellular carcinoma cells. Salvi A, et al. Neoplasia, 2009 Feb. PMID 19177205.
LIM and SH3 protein 1 (Lasp1) is a novel p53 transcriptional target involved in hepatocellular carcinoma. Wang B, et al. J Hepatol, 2009 Mar. PMID 19155088.
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