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Goat Anti-LASS3 / CerS3 Antibody
Peptide-affinity purified goat antibody
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- BACKGROUND
Application 
| WB, E |
|---|---|
| Primary Accession | Q8IU89 |
| Other Accession | NP_849164, 204219, 545975 (mouse), 499174 (rat) |
| Reactivity | Rat |
| Predicted | Human, Mouse |
| Host | Goat |
| Clonality | Polyclonal |
| Concentration | 100ug/200ul |
| Isotype | IgG |
| Calculated MW | 46316 Da |
| Gene ID | 204219 |
|---|---|
| Other Names | Ceramide synthase 3, CerS3, 2.3.1.24, Dihydroceramide synthase 3, LAG1 longevity assurance homolog 3, CERS3, LASS3 |
| Format | 0.5 mg IgG/ml in Tris saline (20mM Tris pH7.3, 150mM NaCl), 0.02% sodium azide, with 0.5% bovine serum albumin |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | Goat Anti-LASS3 / CerS3 Antibody is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | CERS3 {ECO:0000303|PubMed:17977534, ECO:0000312|HGNC:HGNC:23752} |
|---|---|
| Function | Ceramide synthase that catalyzes the transfer of the acyl chain from acyl-CoA to a sphingoid base, with high selectivity toward very- and ultra-long-chain fatty acyl-CoA (chain length greater than C22) (PubMed:17977534, PubMed:22038835, PubMed:26887952). N-acylates sphinganine and sphingosine bases to form dihydroceramides and ceramides in de novo synthesis and salvage pathways, respectively (PubMed:17977534, PubMed:22038835, PubMed:26887952). It is crucial for the synthesis of ultra-long-chain ceramides in the epidermis, to maintain epidermal lipid homeostasis and terminal differentiation (PubMed:23754960). |
| Cellular Location | Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:Q1A3B0}; Multi-pass membrane protein |
| Tissue Location | Expressed in the epidermis, where it localizes at the interface between the stratum granulosum and the stratum corneum (at protein level). |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
References
A meta-analysis of four genome-wide association studies of survival to age 90 years or older: the Cohorts for Heart and Aging Research in Genomic Epidemiology Consortium. Newman AB, et al. J Gerontol A Biol Sci Med Sci, 2010 May. PMID 20304771.
Toward a confocal subcellular atlas of the human proteome. Barbe L, et al. Mol Cell Proteomics, 2008 Mar. PMID 18029348.
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Gerhard DS, et al. Genome Res, 2004 Oct. PMID 15489334.
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932.
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